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Abscopal effect of radiation on bone metastases of breast cancer: A case report |
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| Authors: | Henry WC Leung Shyh-Yau Wang Huang Jin-Jhih |
| Institution: | 1. Department of Radiation Oncology, An-Nan Hospital, China Medical University, No. 66, Sec. 2, Changhe Rd., Annan Dist., Tainan, Taiwan;2. Department of Radiology, An Nan Hospital, China Medical University, No. 66, Sec. 2, Changhe Rd., Annan Dist., Tainan, Taiwan;3. Department of Pharmacy, An Nan Hospital, China Medical University, No. 66, Sec. 2, Changhe Rd., Annan Dist., Tainan, Taiwan |
| Abstract: | The abscopal effect is defined as the clearance of distant tumors after applying localized irradiation to a particular tumor site. It has been proposed that a mechanism for the abscopal effect might be the activation of the immune system, which leads to immunogenic tumor cell death. Here, we describe a woman with advanced breast cancer that received modified ablative radiation therapy that targeted her primary breast tumor. She experienced an apparent regression of metastatic mass in the thoracic spine. This case supported the hypothesis that the abscopal effect might be attributable to an activation of the systemic immune response. |
| Keywords: | Abscopal effect bone metastases radiotherapy breast cancer spontaneous regression |