Prognostic value of Ki67 antigen expression in basal cell carcinomas |
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| Authors: | E. HEALY B. ANGUS C.M. LAWRENCK J.L. REES |
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| Affiliation: | Department of Dermatology, Universiy of Newcastle upon type NH I 4LP, U.K.;Pathology, Universiy of Newcastle upon type NH I 4LP, U.K. |
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| Abstract: | Summary Recurrence of basal cell carcinoma (BCC) following treatment is a common event and long-term follow-up of all patients presenting with a primary BCC has been recommended. Proliferation indices have been recognized as important prognostic factors in several tumour types in a variety of cancer systems, being significantly elevated in more aggressive lesions. We have examined 51 BCCs (17 non-recurrent tumours [group 1]. 17 original tumours which later recurred [group 2-0]. and the corresponding 17 recurrent specimens [group 2-R] for Ki67 antigen expression, a proliferalionassociated antigen using immunohistochemistry with the monoclonal antibody MIB1. There was a significant increase in the percentage positive for MIB1 in the Group 2-0 as compared with the group 1 BCCs (P
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