| 麻黄碱对缺氧缺血新生大鼠海马神经细胞的保护作用 |
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| 引用本文： | 许蓓,肖农,张晓萍.麻黄碱对缺氧缺血新生大鼠海马神经细胞的保护作用[J].第三军医大学学报,2009,31(24):2432-2435. |
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| 作者姓名： | 许蓓 肖农 张晓萍 |
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| 作者单位： | 1. 重庆医科大学附属儿童医院康复中心,重庆,400014
2. 重庆医科大学附属儿童医院儿科研究所,重庆,400014 |
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| 基金项目： | 重庆市卫牛局科研项目 |
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| 摘 要： | 目的 观察麻黄碱(ephedrine,EPH)埘大鼠缺氧缺血性脑损伤(hypoxic-ischemic brain damage,HIBD)海马神经细胞调亡及远期学习记忆能力的影响.方法 新生SD大鼠(7日龄)按随机数宁表法分为麻黄碱组(EPH组)、对照组(Con组)和假于术组(Sham组).分别于HIBD后6、12 h,1、3、7 d采用免疫组织化学检测符组大鼠bcl-2蚩白和bax蛋白在海马区的表达,HIBD后4周 Morris水迷宫测试其学爿记忆能力.结果 EPH组bcl-2表达较Con组显著增高,1 d时达到高峰,3 d后逐渐下降;bax蛋门表达较Con组明显降低,1 d时最低;各组平均潜伏时间均逐渐缩短,EPH组3-5 d时平均潜伏时间较Con组明显缩短.EPH组穿越平台次数及在目标象限游泳距离与总距离百分比均高于Con组.结论 麻黄碱可使新牛大鼠HIBD后海马bel-2蛋白表达增加和bax蛋白表达减少,并能提高远期学习记忆能力.
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| 关 键 词： | 缺氧缺血性脑损伤 麻黄碱 水迷宫 |
Ephedrine protects hippocampal neurons in neonatal rats after hypoxic-ischemic brain injury |
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| XU Bei,XIAO Nong,ZHANG Xiao-ping.Ephedrine protects hippocampal neurons in neonatal rats after hypoxic-ischemic brain injury[J].Acta Academiae Medicinae Militaris Tertiae,2009,31(24):2432-2435. |
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| Authors: | XU Bei XIAO Nong ZHANG Xiao-ping |
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| Institution: | XU Bei1,XIAO Nong1,ZHANG Xiao-ping2 (1Department of Rehabilitation Center,Children's Hospital,2 Institute of Pediatrics,Chongqing Medical University,Chongqing 400014,China) |
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| Abstract: | Objective To explore the effects of ephedrine on the hippocampal cell apoptosis and behavioral performance after hypoxia-ischemia brain injury in neonatal rats.Methods Totally 90 7-day rats were randomly divided into 3 groups,ephedrine treatment group,model group,and sham group.Hypoxia-ischemia brain injury model was established by permanently ligating right common carotid artery.Ephedrine (1.5 mg/kg,once per day) was injected intraperitoneally to the rats of ephedrine treatment group for 7 d,and the rats o... |
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| Keywords: | bel-2 bax hypoxic-ischemic brain damage ephedrine bcl-2 bax Morris water maze |
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