室管膜下瘤:一例报告并文献复习

目的 报告1例室管膜下瘤患者的临床和病理学特征,并复习相关文献.方法 与结果男性患者,54岁.突发意识障碍,全身抽搐,短暂失忆.MRI检查显示左侧侧脑室内占位性病变,增强扫描部分区域明显强化,脑室扩张、积水.手术中可见肿瘤组织呈灰白色,边界清楚,血运中等,质地柔软,分块切除.光学显微镜观察,肿瘤细胞成团、成簇分布于致密...

Subependymoma: a case report and the review of literatures

Objective To report a rare case of subependymoma and explore its clinical and pathological features.Methods The clinical presentations,histopathological and immunohistochemical features of a case of subependymoma were studied retrospectively.The related literatures were also reviewed.Results A 54-year-old male patient presented with sudden loss of awareness,generalized convulsion and transient loss of memory.Magnetic resonance imaging(MRI) showed a space-occupying lesion located in the left ventricle.The lesion was focally enhanced.Lateral ventricle was enlarged with hydrocephalus.During operation,tumor tissue was soft,grayish in colour and well circumscribed.The blood supply was moderate.The tumor nodule was resected,measuring 3 cm X 2 cm X 2 cm. Microscopically,tumor cells distributed in conglobation or group in dense fibrillary matrix of glia and many microcysts could be seen.Some eosinophilic protein fluid were accumulated in the microcysts.Tumor cells were similar in size without any atypia.Tumor cell nuclei were round or elliptical and no karyokinesis was seen.Immuohistochemistry showed glial fibrillary acidic protein(GFAP) and nestin were positively expressed in tumor cells.The Ki-67 labeling index was less than 1%.Neuronal nuclear antigen(NeuN) was negatively expressed.The patient was followed up for 6 months and no recurrence was found. Conclusion Subependymoma is one of the rare benign tumors of the central nervous system.High incidence appears in male adults.Its long-term prognosis is good after surgical complete resection.