| Langendorff灌流的离体兔心房颤动模型的建立 |
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| 引用本文： | 刘彤,许纲,李广平,陈元禄,黄体钢.Langendorff灌流的离体兔心房颤动模型的建立[J].中华实验外科杂志,2004,21(11):1392-1393. |
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| 作者姓名： | 刘彤 许纲 李广平 陈元禄 黄体钢 |
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| 作者单位： | 300211,天津医科大学第二医院心脏科 |
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| 摘 要： | 目的 探讨建立Langendorff灌流的离体兔心房颤动 (房颤 )模型的方法。 方法 兔10只建立Langendorff灌流的离体兔房颤模型 ,起始右房压力为 0 ,逐步递增至 12cmH2 O (1cmH2 O =0 .0 98kPa) ,在每个压力水平分别给予S1S2刺激诱发心房颤动。结果 9只兔心脏成功诱发房颤 ,房颤诱发成功率为 90 % ;随着心房压力的升高 ,房颤诱发率升高。结论 改进后的模型诱发房颤成功率高 ,方法简便 ,易于掌握及推广。
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| 关 键 词： | 心房颤动 模型 动物 兔 |
| 修稿时间： | 2004年5月23日 |
A langendorff-perfused rabbit heart model of atrial fibrillation |
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| LIU Tong,XU Gang,LI Guang-ping,et al..A langendorff-perfused rabbit heart model of atrial fibrillation[J].Chinese Journal of Experimental Surgery,2004,21(11):1392-1393. |
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| Authors: | LIU Tong XU Gang LI Guang-ping |
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| Institution: | LIU Tong,XU Gang,LI Guang-ping,et al.Department of Cardiology,Second Hospital of Tianjin Medical University,Tianjin 300211,China |
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| Abstract: | Objective To discuss the method of establishing a langendorff-perfused rabbit heart model of atrial fibrillation (AF).Methods Ten isolated Langendorff-perfused rabbit heart models of AF were established.The right atrial pressure was increased from 0 to 12 cmH 2O step by step.At each pressure level,the method of S1S2 stimulation was used to induce AF.Results AF was induced in 9 rabbit hearts with the success rate being 90%.With the elevation of right atrial pressure,the inducibility of AF was also increased.Conclusion Modified model has high inducibility of AF and is easy to learn and extend. |
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| Keywords: | Atrial fibrillation Model animal Rabbit |
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