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| 顺铂和长春瑞滨联合放疗对大鼠脊髓损伤的实验研究 | |
| 引用本文： | 曲 怡,王媛媛,吕广艳,王若雨,刘 畅,邹丽娟. 顺铂和长春瑞滨联合放疗对大鼠脊髓损伤的实验研究[J]. 大连医科大学学报, 2009, 31(1): 9-13 |
| 作者姓名： | 曲 怡 王媛媛 吕广艳 王若雨 刘 畅 邹丽娟 |
| 作者单位： | 1. 大连医科大学,附属第二医院,肿瘤放疗科,辽宁,大连116027 2. 大连医科大学,分析测试中心,辽宁,大连116044 3. 大连大学,附属中山医院,肿瘤科,辽宁,大连116001 4. 中国医科大学,89期七年制,辽宁,沈阳,110003 |
| 摘 要： | [目的]探讨顺铂(cisplatin,DDP)和长春瑞滨(vinorelbine)联合放射治疗对大鼠脊髓损伤的影响。[方法]24只健康雄性Wistar大鼠随机分为4组:正常对照组;单纯放疗组;单纯化疗组;化疗联合放疗组。腹腔分别注射顺铂和长春瑞滨。直线加速器6 MeV电子线照射大鼠胸段脊髓,5 Gy/次,总剂量40 Gy。照射结束后5个月,光镜和电镜下观察脊髓的形态学改变。[结果]光镜下,单纯化疗组脊髓白质、灰质有轻微变化;单纯放疗组脊髓白质出现损伤;化疗联合放疗组脊髓白质、灰质均见明显损伤。电镜下,单纯放疗组髓鞘有轻微变化;单纯化疗组髓鞘有明显损伤;化疗联合放疗组髓鞘损伤严重。[结论]顺铂和长春瑞滨均可引起大鼠脊髓损伤,且顺铂和长春瑞滨联合放射治疗加重大鼠脊髓损伤。 |
| 关 键 词： | 脊髓损伤 化学疗法 顺铂 长春瑞滨 放射疗法 |
Experimental study on injury of rat's spinal cord induced by radiotherapy combined with cisplatin and vinorelbine |
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| QU Yi,WANG Yuan-yuan,L Guang-yan,WANG Ruo-yu,ZOU Li-juan,LIU Chang. Experimental study on injury of rat's spinal cord induced by radiotherapy combined with cisplatin and vinorelbine[J]. Journal of Dalian Medical University, 2009, 31(1): 9-13 | |
| Authors: | QU Yi WANG Yuan-yuan L Guang-yan WANG Ruo-yu ZOU Li-juan LIU Chang |
| Affiliation: | QU Yi,WANG Yuan-yuan,L(U) Guang-yan,WANG Ruo-yu,ZOU Li-juan,LIU Chang |
| Abstract: | [Objective]To explore the injury of rat's spinal cord induced by radiotherapy combined with cisplatin and vinorelbine.[Methods] Twenty-four Wistar rats were randomly divided into 4 groups: normal group,radiotherapy group,cisplatin and vinorelbine group,and combination group.The rats were given cisplatin and ivinorelbine through intraperitoneal injection.The thoracic cord of rats were radiated by 6 MeV electron beam with 5.0 Gy each time and 40.0 Gy in total.Rats from each group were sacrificed after 5 month... |
| Keywords: | spinal cord injury chemotherapy cisplatin vinorelbine radiotherapy |
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