| 兔自体移植静脉狭窄与细胞外基质的关系 |
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| 引用本文： | 朱海龙,杨景学,张卫达,崔勤,陈文生. 兔自体移植静脉狭窄与细胞外基质的关系[J]. 医学争鸣, 2001, 22(5): 407-409 |
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| 作者姓名： | 朱海龙 杨景学 张卫达 崔勤 陈文生 |
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| 作者单位： | 第四军医大学西京医院心血管外科中心, |
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| 摘 要： | 目的观察胶原和弹性纤维的积累及其与自体移植静脉（atuologous vein grafts,AVG)狭窄的关系，方法建立兔自体颈外静脉移植模型，用计算机图像分析，测量胶原和弹性纤维在新生内膜的面积以及Ⅰ，Ⅲ型胶原蛋白表达灰度值，结果，移植后2－12wk胶原和弹性纤维面积逐渐增加，Ⅰ，Ⅲ型胶原蛋白表达也逐渐增强。结论静脉移植后胶原和弹性纤维逐渐积累，其含量与管腔减少正相关，胶原在管腔中的作用大于弹性纤维，胶原蛋白中Ⅰ型胶原作用大于Ⅲ型胶原。
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| 关 键 词： | 自体移植静脉狭窄 细胞外基质 平滑肌细胞 |
| 文章编号： | 1000-2790(2001)05-0407-03 |
| 修稿时间： | 2000-01-18 |
Correlation between extracellular matrix and stenosis of autologous vein grafts in rabbit model |
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| ZHU Hai-Long,YANG Jing-Xue,ZHANG Wei-Da,CUI Qin,CHEN Wen-Sheng. Correlation between extracellular matrix and stenosis of autologous vein grafts in rabbit model[J]. Negative, 2001, 22(5): 407-409 |
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| Authors: | ZHU Hai-Long YANG Jing-Xue ZHANG Wei-Da CUI Qin CHEN Wen-Sheng |
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| Abstract: | AIM To observe the accumulation of collagen and elast in fibres and its correlation with (autologous vein grafts, AVG) cavity loss. METHODS To establish the rabbit model of AVG, the area of collagen and elastin fibres and the expression of collagenⅠand collagen Ⅲ were assayed quan titatively in neointima. RESULTS Area of collagen and elastin fibres incr eased gradually;the percentages of two fibres in intimal area were correlated positively with the cavity loss ra te of the AVG during 4～12 weeks after implantation. The ex-pression of collagenⅠand collagen Ⅲ also increased. CONCLUSION Collagen and elastin fibres accumulate g radually and play a critical role in the cavity loss of the AVG. Collagen is more important than elastin fibres, and collagenⅠplays the main part. |
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| Keywords: | transplanlation autologous veins/transplantation extracellular matrix smooth muslce cell stenosis |
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