| p53基因在肿瘤放疗中的研究进展 |
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| 引用本文： | 王承红.p53基因在肿瘤放疗中的研究进展[J].医学综述,2010,16(2). |
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| 作者姓名： | 王承红 |
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| 作者单位： | 昆明医学院第三附属医院放射治疗中心,昆明,650018 |
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| 摘 要： | p53基因在机体组织细胞的生长、发育与分化等过程中起重要作用,其主要生物学功能是DNA修复,阻滞细胞周期,抑制血管生成,诱导细胞凋亡。基础研究和临床实验研究显示,野生型p53基因具有放射增敏作用,野生型p53基因正是通过阻断细胞周期、影响DNA修复能力、促进与其他基因的相互作用等功能增加肿瘤对射线的敏感性,而p53基因缺失或者突变将会减弱甚至阻断DNA的射线损伤,从而降低放射敏感性的作用。
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| 关 键 词： | p53基因 肿瘤 放射治疗 放射增敏作用 |
Research Progress of the p53 Gene in the Radiotherapy |
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| WANG Cheng-hong.Research Progress of the p53 Gene in the Radiotherapy[J].Medical Recapitulate,2010,16(2). |
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| Authors: | WANG Cheng-hong |
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| Institution: | WANG Cheng-hong.(Department of Radiation Oncology,the Third Affiliated Hospital of Kunming Medical University,Kunming 650018,China) |
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| Abstract: | The p53 gene plays an important role in the growth,development and differentiation of cell.DNA repair,Cell cycle arrest,angiogenesis inhibitor and induced-apoptosis are the main biological function of p53 gene.Basic and clinical researches demonstrated that the wild-p53 gene could enhance the radiosensitivity by blocking cell cycle,affecting DNA repair capacity and promoting the interaction with other genes.The deleted or mutated p53 gene would weaken or even block the DNA damage by the ray,thus,reduce the ... |
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| Keywords: | p53gene Tumour Radiotherapy Radiosensitivity |
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