正常人体心室舒张功能生理性变化特点的超声研究

目的观察正常人体心室舒张功能的演变规律，探讨心室舒张功能生理性减退的基本界限。方法本项目运用无创性超声成像技术，对正常人心室舒张功能进行了血流动力学检测。240名自愿接受体检者．按年龄分为少年组、青年组、中年组和老年组，采用二维超声检测心腔内径，M型超声检测舒张期心室壁弛张速度，频谱多普勒检测左右房室瓣及肺静脉口血流速度以及流速比值，彩色多普勒显示舒张期心室血流充盈时相及持续时间。结果二尖瓣、三尖瓣以及肺静脉口血流的多项参数与年龄增长呈高度相关。正常人心室舒张功能特点是：青少年期为完全正常期．中年期为顺应性减低期，老年期为舒张功能减低期。心室舒张功能的减退左室先于右室。结论正常人心室舒张功能随年龄增长存在生理性减退。

Echocardiographical study on physiological characteristics of ventricular diastolic function in normal individual

Objective To investigate the regularity of changes an d the base line of physiological deficiency of ventricular diastolic function in normal individuals. Methods Non-invasive echocardiography was employed for monitoring hemodynamics of the ventricular diastolic function in n ormal individuals. 240 volunteers were divided into four groups by age, i.e. juv enile, youth, middle-aged and elderly groups. Items of examination included the diameter of cardiac chambers by two-dimensional (2D) echogram, velocity of dia stole of ventricular wall by M mode, velocity and ratio of blood flow at left an d right atrio-ventricular valves and pulmonary vein by spectral Doppler, fillin g phase and duration of filling of ventricles in diastolic phase by color Dopple r. Results Of mitral valve, tricuspid valve and pulmonary vein, a series of dynamic parameters of blood flow were correlated closely with the a ge. The ventricular diastolic function of normal person deteriorated physiologic ally with the passage of years, characterized by a normal stage in juvenile and young ages, compliant decreased stage in middle-age, and declined functional st age in aged. The declination course started in the left ventricle prior to the r ightventaide. Conclusion The results of the present study may b e helpful for further clinical researches on the mechanisms of changes in human ventricular diastolic function.