| Detection of Laminin in Serum and Ascites from Patients with Epithelial Ovarian Tumor |
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| 作者姓名： | 初永丽 杨元先 林美华 王泽华 |
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| 作者单位： | CHU Yongli，YANG Yuanxian，LIN Meihua，WANG Zehua Department of Obstetrics and Gynecology，Xiehe Hosipital，Tongji Medical College of Huazhong University of science and Technology，Wuhan 430022 |
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| 基金项目： | This project was supported by a grant from the National
Natural Sciences Foundation of China (No.30 0 70 786 ) and
Hubei Science and Technology Department Foundation
(No.0 1P15 0 5 ) |
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| 摘 要： | The ovarian malignant tumor is one kind oftumors which threaten women' s health seriously.It is difficult to be early diagnosed and monitoredafter operation.To find the specific serum markeris always one of the important topics of ovarianmalignant tumor research.Laminin (LN) is onemember of the integrins family and is the majorcomponent of extracellular matrix.When bindingto LN receptor,LN can regulate adhesion,diffu-sion,migration and proliferation of cells.It is af-firmed that LN has a c…
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| 收稿时间： | 21 September 2007 |
Detection of laminin in serum and ascites from patients with epithelial ovarian tumor |
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| Chu Yongli,Yang Yuanxian,Lin Meihua,Wang Zehua.Detection of Laminin in Serum and Ascites from Patients with Epithelial Ovarian Tumor[J].Journal of Zuazhong University of Science and Technology: Medical Edition,2002,22(1):58-59. |
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| Authors: | Chu Yongli Yang Yuanxian Lin Meihua Wang Zehua |
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| Institution: | Department of Obstetrics and Gynecology, Xiehe Hosipital , Tongji Medical College of Huazhong University of science and Technology, Wuhan 430022 |
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| Abstract: | The change in serum laminin (LN) level and its clinical significance in epithelial ovarian tumor were investigated. The LN levels in serum and ascites samples from 69 patients with epithelial ovarian tumor and 42 cases as control group before and after operation were analyzed by radioimmunoassay. The results showed that the serum LN levels in the patients with malignant tumors (157.85 +/- 14.37 ng/ml) were significantly higher than that in the control group (125.14 +/- 7.03 ng/ml) and in the patients with benign tumors (128.36 +/- 8.75 ng/ml) (both P < 0.01) before operation. The serum LN levels in the malignant group were decreased significantly after operation as compared with those before operation (P < 0.05). The serum LN levels in low-differentiated tumors was higher than those in moderate-differentiated tumors and high-differentiated tumors (P < 0.05). The LN levels in ascites (172.94 +/- 15.26 ng/ml) was significantly higher than in serum (161.34 +/- 6.59 ng/ml) (P < 0.05) in malignant tumors. The serum LN levels in the patients with lymph node metastasis (165.41 +/- 19.91 ng/ml) was obviously higher than those without lymph node metastasis (152.35 +/- 10.34 ng/ml) (P < 0.05). It was concluded that LN levels in serum and acistis were remarkably increased in malignant epithelial ovarian tumors, suggesting that LN might be one of important diameters reflecting tumor biological characteristics. |
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| Keywords: | ovarian tumor laminin radioimmunoassay |
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