| The Expression of the Apoptosis—Suppressive Gene bcl—2 in the Tissue of Colon Carcinoma |
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| 引用本文： | 黄文广,姚璇. The Expression of the Apoptosis—Suppressive Gene bcl—2 in the Tissue of Colon Carcinoma[J]. 华中科技大学学报(医学英德文版), 2002, 22(3): 218-220. DOI: 10.1007/BF02828184 |
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| 作者姓名： | 黄文广 姚璇 |
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| 作者单位： | [1]DepartmentofGeneralSurgery,XieheHospital,TongjiMedicalCollege,HuazhongUniversityofScienceandTechnology,Wuhan430022 [2]DepartmentofGeneralSurgery,XieheHospital,TongjiMedicalCollege,HuazhongUniversityofSci |
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| 基金项目： | a grantfromNational Natural Science Foundationof China(No.3 9970 693 ) |
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| 摘 要： | The role of bcl-2 in the pathogenesis of colorectal tumor were studied.The expression of bcl-2 in the colorectal carcinoma and incisional edge tissue of tumor was detected by using SABC method.The results showed that the positive rate of bcl-2 was 69.6% in colorectal carcinoma and 47.6% in the incisional edge tissue respectively, with the difference being very significant (P=0.001).Bcl-2 positive rate was associated with Dukes‘ stage ,but had nothing to do with histo-logical classification.It was concluded that bcl-2 might play a significant role in the development of colorectal carcinoma.
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| 关 键 词： | 凋亡抑制基因 bcl－2 结肠癌组织 表达 临床病理 |
| 收稿时间： | 2001-07-07 |
The expression of the apoptosis-suppressive gene bcl-2 in the tissue of colon carcinoma |
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| Huang Wenguang,Yao Xuan. The expression of the apoptosis-suppressive gene bcl-2 in the tissue of colon carcinoma[J]. Journal of Huazhong University of Science and Technology. Medical sciences, 2002, 22(3): 218-220. DOI: 10.1007/BF02828184 |
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| Authors: | Huang Wenguang Yao Xuan |
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| Affiliation: | Department of General Surgery, Xiehe Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022 |
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| Abstract: | The role of bcl 2 in the pathogenesis of colorectal tumor were studied. The exp ression of bcl 2 in the colorectal carcinoma and incisional edge tissue of tumo r was detected by using SABC method. The results showed that the positive rate o f bcl 2 was 69.6 % in colorectal carcinoma and 47.6 % in the incisional edge ti ssue respectively, with the difference being very significant ( P =0.001). B cl 2 positive rate was associated with Dukes' stage, but had nothing to do with histological classification. It was concluded that bcl 2 might play a signific ant role in the development of colorectal carcinoma. |
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| Keywords: | colorectal carcinoma bcl 2 oncoprotein apop tosis immunohistochemistry |
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