| Chronic Kidney Isograft and Allograft Rejection |
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| 作者姓名： | 严群 张鹏 杨传永 |
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| 作者单位： | [1]TheSurgicalResearchLaboratosy,TongjiMedicalCollege,HuazhongUniversityofScienceandTechnology,Wuhan430030 [2]TheSurgicalResearchLaboratosy,TongjiMedicalCollege,HuazhongUniversityofScienceandTechnology,Wuha |
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| 摘 要： | In this study antigen-independent factor in the pathogenesis of chronic rejection of organ transplants was examined.Kidney isografts and allografts were transplanted orthotopically into bilaterally nephroectomized rat recipients and studied functionaaly,morphologically and immunohistologically,at serial intervals up to 52 weeks after transplantation.Allograft recipients developed progressive proteinuria after 12 weeks,with gradual renal failure ultimately leading to death.At the same time,morphological changes,including progressive arteriosclerosis and glomerulosclerosis ,tubular atrophy and interstitial fibrosis,developed.Immunohistologically,macrophages infiltrated glomeruli during this period and cytokines became unregulated.Our results showed that antigen-independent functional and morphological changes occurred in long-tern kidney isografts and mimicked those appearing much earlier in allografts that reject chronically.Initial injury and extent of functioning renal mass is suggested to be important factor for such late changes.
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| 关 键 词： | 同种异体移植 肾移植 慢性排斥 同系移植 |
| 收稿时间： | 19 April 2001 |
Chronic kidney isograft and allograft rejection |
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| Yan Qun,Zhang Peng,Yang Chuanyong.Chronic Kidney Isograft and Allograft Rejection[J].Journal of Zuazhong University of Science and Technology: Medical Edition,2002,22(3):253-254. |
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| Authors: | Yan Qun Zhang Peng Yang Chuanyong |
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| Institution: | The Surgical Research Laboratosy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030 |
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| Abstract: | In this study antigen independent factor in the pathogenesis of chronic rejection of organ transplants was examined. Kidney isografts and allografts were transplanted orthotopically into bilaterally nephroectomized rat recipients and studied functionally, morphologically and immunohistologically, at serial intervals up to 52 weeks after transplantation. Allograft recipients developed progressive proteinuria after 12 weeks, with gradual renal failure ultimately leading to death. At the same time, morphological changes, including progressive arteriosclerosis and glomerulosclerosis, tubular atrophy and interstitial fibrosis, developed. Immunohistologically, macrophages infiltrated glomeruli during this period and cytokines became unregulated. Our results showed that antigen independent functional and morphological changes occurred in long term kidney isografts and mimicked those appearing much earlier in allografts that reject chronically. Initial injury and extent of functioning renal mass is suggested to be important factor for such late changes. |
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| Keywords: | isograft allogaft chronic rejection |
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