疾病蛋白质组学研究进展

在人类基因组草图完成的后基因组时代,生命科学面临的最重要任务之一将是对人类基因的注释与确认,即人类基因组中约1/3的基因及其功能有待于蛋白质水平上的揭示与确认。其中,在功能蛋白质组领域内,疾病蛋白质组学在医学和生物制药方面具有发现新分子药靶、生物标志物的巨大的潜力。本文对疾病蛋白质组学在国外、国内研究现状及目前所存在的问题、发展趋势等几方面作简要概述。

Progress in human disease proteomics

In the post-genomic era,with the accomplishment of the sequence mapping of human genome,one of the most important tasks for life science is the explanation and identification of human genome,that is,about 1/3genes of human genome and their functions need further revealment and verific-ation on the level of protein.In the field of functional proteomics,the human disease proteomics shows great potential in the discovery of new molecular targets and biomarkers for medicine and biopharmacy.In this article,we have made a concise discussion on the current status,existing problems and future development in the research of human disease proteomics both in and out of China.