| 重楼总皂苷巴布剂的基质处方优化及含量测定 |
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| 引用本文： | 罗云,熊志伟,梁新丽,赵国巍,张婧,赵海平,杨明,廖正根. 重楼总皂苷巴布剂的基质处方优化及含量测定[J]. 中国实验方剂学杂志, 2014, 20(22): 5-9 |
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| 作者姓名： | 罗云 熊志伟 梁新丽 赵国巍 张婧 赵海平 杨明 廖正根 |
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| 作者单位： | 江西中医药大学 现代中药制剂教育部重点实验室, 南昌 330004;江西中医药大学 现代中药制剂教育部重点实验室, 南昌 330004;江西中医药大学 现代中药制剂教育部重点实验室, 南昌 330004;江西中医药大学 现代中药制剂教育部重点实验室, 南昌 330004;江西中医药大学 现代中药制剂教育部重点实验室, 南昌 330004;江西中医药大学 现代中药制剂教育部重点实验室, 南昌 330004;江西中医药大学 现代中药制剂教育部重点实验室, 南昌 330004;江西中医药大学 现代中药制剂教育部重点实验室, 南昌 330004 |
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| 基金项目： | 江西省科技计划项目(20123BBG70200);赣鄱英才555工程领军人才培养计划(赣财教指[2013]296号) |
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| 摘 要： | 目的:优选重楼总皂苷巴布剂的基质处方并建立其含量测定方法。方法:以涂展性、透布性、均匀性、赋形性、皮肤追随性、黏附性、反复揭帖性为综合评价指标,在预试验基础上,选择明胶、聚丙烯酸钠、甘油及聚乙烯吡咯烷酮-K30用量为考察因素,采用均匀设计法优选重楼总皂苷巴布剂的基质处方;利用HPLC测定重楼皂苷Ⅱ,Ⅶ含量,流动相乙腈(A)-水(B)梯度洗脱(0~40 min,30%~60%A;40~50 min,60%~30%A;50~55 min,30%A),流速1.0 m L·min-1,检测波长203 nm。结果:最佳基质处方为明胶-聚丙烯酸钠-聚乙烯吡咯烷酮-K30-甘油-甘羟铝-氮酮-重楼总皂苷(2.0∶4.0∶1.25∶15∶0.16∶1.2∶4);重楼皂苷Ⅱ,Ⅶ线性范围分别为0.055~5.5,0.086 8~8.68μg,质量分数分别为1.06,3.79 mg·g-1。结论:制备的巴布剂载药量大,具有良好的黏附性和外观。建立的含量测定方法简便、准确可靠、重复性好,适用于该制剂的质量评价。
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| 关 键 词： | 重楼总皂苷 巴布剂 均匀设计法 基质处方 质量评价 |
| 收稿时间： | 2014-06-10 |
Optimization of Matrix Formulation and Content Determination of Paridis Rhizoma Total Saponins Cataplasms |
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| LUO Yun,XIONG Zhi-wei,LIANG Xin-li,ZHAO Guo-wei,ZHANG Jing,ZHAO Hai-ping,YANG Ming and LIAO Zheng-gen. Optimization of Matrix Formulation and Content Determination of Paridis Rhizoma Total Saponins Cataplasms[J]. China Journal of Experimental Traditional Medical Formulae, 2014, 20(22): 5-9 |
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| Authors: | LUO Yun XIONG Zhi-wei LIANG Xin-li ZHAO Guo-wei ZHANG Jing ZHAO Hai-ping YANG Ming LIAO Zheng-gen |
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| Affiliation: | Key Laboratory of Modern Preparation of Traditional Chinese Medicine(TCM), Ministry of Education, Jiangxi University of TCM, Nanchang 330004, China;Key Laboratory of Modern Preparation of Traditional Chinese Medicine(TCM), Ministry of Education, Jiangxi University of TCM, Nanchang 330004, China;Key Laboratory of Modern Preparation of Traditional Chinese Medicine(TCM), Ministry of Education, Jiangxi University of TCM, Nanchang 330004, China;Key Laboratory of Modern Preparation of Traditional Chinese Medicine(TCM), Ministry of Education, Jiangxi University of TCM, Nanchang 330004, China;Key Laboratory of Modern Preparation of Traditional Chinese Medicine(TCM), Ministry of Education, Jiangxi University of TCM, Nanchang 330004, China;Key Laboratory of Modern Preparation of Traditional Chinese Medicine(TCM), Ministry of Education, Jiangxi University of TCM, Nanchang 330004, China;Key Laboratory of Modern Preparation of Traditional Chinese Medicine(TCM), Ministry of Education, Jiangxi University of TCM, Nanchang 330004, China;Key Laboratory of Modern Preparation of Traditional Chinese Medicine(TCM), Ministry of Education, Jiangxi University of TCM, Nanchang 330004, China |
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| Abstract: | |
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| Keywords: | total saponins from Paridis Rhizoma cataplasms uniform design matrix formulation quality evaluation |
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