Is there a role for Notch signalling in human breast cancer? |
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| Authors: | Keith Brennan Anthony MC Brown |
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| Affiliation: | (1) School of Biological Sciences, University of Manchester, UK;(2) Strang Cancer Research Laboratory at The Rockefeller University, New York, USA;(3) Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, USA |
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| Abstract: | Aberrant Notch signalling has been observed in several human cancers, including acute T-cell lymphoblastic leukaemia and cervical cancer, and is strongly implicated in tumourigenesis. Unregulated Notch signalling in the mouse mammary gland leads to tumour formation. These results raise the possibility that Notch signalling might play a role in human breast cancer. There are currently few reports that address this question directly and this appears to be an area worthy of further investigation. |
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