糖皮质激素对鼻息肉组织中eotaxin蛋白的影响

目的:探讨糖皮质激素治疗鼻息肉的可能机制。方法:随机将15例鼻息肉患者均分为强的松治疗组、地塞米松治疗组和未治疗组,以同期手术的5例鼻中隔偏曲者的下鼻甲黏膜组织作对照,用免疫组化法测定鼻息肉组织中嗜酸细胞趋化因子(eotaxin)蛋白的表达。结果:激素未治疗组eotaxin蛋白的表达比对照组显著增高(P<0.01);激素治疗组eotaxin蛋白表达下降,与未治疗组比较差异有统计学意义(P<0.01),与对照组比较差异无统计学意义(P>0.05)。结论:Eotaxin蛋白是诱导嗜酸细胞在鼻息肉组织中浸润的重要趋化因子,糖皮质激素可下调eotaxin蛋白的表达,发挥抗嗜酸细胞炎症的作用。

Effect of glucocorticoids on eotaxin expression in nasal polyps

Objective: To explore the possible mechanism of glucocorticoids on nasal polyps.Methods: Eotaxin protein expression was measured by immunohistochemical techniques in 5 nasal polypous tissue specimens following 30 mg predisone oral doses per day for 7 days,5 nasal polypous tissue specimens following 10 mg dexamethasone intravenous drops,5 without any treatment and compared with the results from the inferior turbinate tissue specimens.Results: The protein level of eotaxin significantly elevated in the nasal polyps compared to the controls(P<(0.01),) whereas it significantly decreased in the treatment group compared with the untreatment group(P<(0.01),) and similar to the controls(P>0.05).Conclusion: Because eotaxin actively participates in the process of eosinophilic inflammation,glucocorticoids play an important role in anti-inflammation by down-regulation of eotaxin.