Gamma-carboxyglutamate in normal and pathological human middle ear bones |
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| Authors: | Zajic Gary Graham Malcolm D. Schacht Jochen |
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| Affiliation: | (1) Kresge Hearing Research Institute, The University of Michigan, 48109 Ann Arbor, Michigan, USA;(2) Department of Otorhinolaryngology, The University of Michigan, 48109 Ann Arbor, Michigan, USA |
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| Abstract: | Summary The presence of the amino acid  -carboxyglutamate (GLA) was established in human middle ear bones. Proteins containing GLA have been described as being associated with normal as well as pathological calcifications. The GLA content of human incus, malleus, and stapes with 1–2 nmol/mg bone is in the range previously reported for a variety of bone. A limited number of samples with middle ear pathology, including otosclerosis, did not show altered GLA levels. |
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| Keywords: | ![]("</a) /content/u03q5r23360j1624/xxlarge947.gif" alt=" gamma" align=" MIDDLE" BORDER=" 0" >-Carboxyglutamate Amino acid analysis Middle ear ossicles Pathology |
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