饮酒对男性原发性高血压患者降压疗效的影响

目的探讨男性原发性高血压患者ACEI(苯那普利)治疗期间饮用白酒对降压疗效的影响。方法采用前瞻性队列研究方法,用多元线性回归和Logistic回归对资料进行统计分析。结果经过15天ACEI治疗,饮酒组收缩压和舒张压下降幅度明显低于非饮酒组,且和饮酒量呈负相关剂量反应关系。其中,每天饮酒大于50ml饮酒组的收缩压和舒张压下降幅度与非饮酒组相比,分别少下降5.26mmHg(0.70kPa)(P=0.0116)和3.32mmHg(0.44kPa)(P=0.0349)。Logistic回归分析发现,每天饮酒大于50ml饮酒组,其收缩压降压有效率为非饮酒组的45%(P=0.0493),舒张压降压有效率为非饮酒组的76%(P=0.4750),但未达到统计显著性差异。结论男性原发性高血压患者在ACEI治疗期间饮用白酒降低降压疗效。

Influence of alcohol consumption on effectiveness of antihypertensive in male patients with essential hypertension

OBJECTIVE: To explore the influence of alcohol consumption during ACEI (Benazepril) therapy on effectiveness of antihypertensive in male patients with essential hypertension. METHODS: A prospective cohort study was made and multiple linear regression and multiple logistic regression models were applied to data analysis. RESULTS: After 15 days ACEI therapy, the decrease in systolic blood pressure (deltaSBP) and diastolic blood pressure (deltaDBP) in alcohol-drinking groups was clearly smaller than that of non-drinking group. An inverse dose-response relation between alcohol drinking and (deltaSBP) as well as (deltaDBP) was observed either. To the non-alcohol-drinking group, subjects with alcohol-drinking more than 50 ml per day showed 5.26 mmHg (0.70 kPa) (P = 0.0116) and 3.32 mmHg (0.44kPa) (P = 0.0349) decreased in NSBP and DDBP, respectively. Logistic regression analysis demonstrated that the alcohol-drinking group's effect rate of antihypertensive were 45% lower (P = 0.0493) in SBP drop and 76% lower (P = 0.4750) in DBP drop respectively compared with non-and alcohol-drinking groups. CONCLUSION: Alcohol drinking during ACEI therapy can lower the effectiveness of antihypertensive in male patients with essential hypertension.