| 不同种类离体皮肤及人工合成膜对川芎贴膏体外透皮试验的影响 |
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| 引用本文： | 祖强,赵晓莉,狄留庆,黄耀洲,于燕燕,黄燕.不同种类离体皮肤及人工合成膜对川芎贴膏体外透皮试验的影响[J].药学与临床研究,2006,14(6):358-360. |
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| 作者姓名： | 祖强 赵晓莉 狄留庆 黄耀洲 于燕燕 黄燕 |
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| 作者单位： | 南京中医药大学,南京,210029 |
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| 基金项目： | 江苏省教育厅高新技术产业化项目;南京中医药大学校科研和教改项目 |
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| 摘 要： | 目的对川芎贴膏体外透皮试验用皮肤作比较研究,选择适宜亲水性成分的实验皮肤并对离体皮肤的前处理方法加以规范。初步为中药经皮给药制剂体外扩散试验评价体系的建立奠定基础。方法应用TP-5型智能透皮扩散仪,以川芎贴膏中盐酸川芎嗪为考察指标,采用紫外分光光度法测定,比较不同种类离体皮肤及人工合成膜对川芎贴膏经皮渗透参数的影响。结果累积渗透量及透皮速率:硝酸纤维素膜>裸鼠>小鼠>大鼠>兔>硅橡胶>乳猪>蛇蜕;时滞:硅橡胶>硝酸纤维素>蛇蜕>小鼠>兔>裸鼠>大鼠>乳猪。结论硝酸纤维素膜可作为适宜亲水性成分盐酸川芎嗪体外经皮渗透实验的理想皮肤模型。
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| 关 键 词： | 川芎贴膏 盐酸川芎嗪 经皮渗透 离体皮肤 人工合成膜 TP-5型智能透皮扩散仪 |
| 文章编号： | 1007-306(2006)06-358-03 |
| 修稿时间： | 2006年8月24日 |
Comparison of Percutaneous Permeability of Chuan Xiong Adhesive Plaster on Excised Skins and Synthetic Membranes In Vitro |
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| ZU Qiang,ZHAO Xiao-li,DI Liu-qing,HUANG Yao-zhou,YU Yan-yan,HUANG Yan.Comparison of Percutaneous Permeability of Chuan Xiong Adhesive Plaster on Excised Skins and Synthetic Membranes In Vitro[J].Pharmacertical and Clinical Research,2006,14(6):358-360. |
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| Authors: | ZU Qiang ZHAO Xiao-li DI Liu-qing HUANG Yao-zhou YU Yan-yan HUANG Yan |
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| Institution: | Nanjing 210029 |
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| Abstract: | OBJECTIVE To assess the percutaneous permeability of ChuanXiong Adhesive Plaster in the comparison of different animal skins and synthetic membranes.METHOD TP-5 automatic diffusion apparatus was adopted for in vitro skin permeation.The permeat experiments were accomplished by testing the deposit of ligustrazine hydrochloride onto various animal skins and synthetic membranes.RESULTS\ The order of cumulative amount and permeat rate:pyroxylin hairless mouse>mouse>rat>rabbit>silicone rubber>porket>snake slough.Lag time:silicone rubber>pyroxylin>snake slough>mouse>rabbit>hairless mouse>rat>porket.CONCLUSION Cellulose nitrate filter can be regarded as a good model for the study of percutanous permeability of Ligustrazine hydrochloride. |
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| Keywords: | ChuanXiong Adhesive Plaster Percutaneous permeability Ligustrazine hydrochloride Excised skin Synthetic membranes TP-5 automatic diffusion apparatus |
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