| 农吉利碱凝胶剂体外透皮与初步药效学研究 |
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| 引用本文： | 周敏敏,赵丹丹,章德军,黄绳武. 农吉利碱凝胶剂体外透皮与初步药效学研究[J]. 中国现代应用药学, 2014, 31(8): 968-973 |
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| 作者姓名： | 周敏敏 赵丹丹 章德军 黄绳武 |
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| 作者单位： | 浙江中医药大学，杭州 310053;浙江中医药大学，杭州 310053;浙江中医药大学，杭州 310053;浙江中医药大学，杭州 310053 |
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| 摘 要： | 目的研究农吉利碱凝胶剂体外透皮性能，并考察其对小鼠鳞状细胞癌的初步药效作用。方法采用立式Franz扩散池，进行农吉利碱凝胶剂体外透皮试验；以小鼠鳞状细胞癌为动物模型，考察农吉利碱凝胶剂疗效。结果农吉利碱凝胶剂体外透皮性能良好，农吉利碱凝胶剂对小鼠鳞状细胞癌有明显抑制作用，高剂量组抑瘤率达35．26％。结论农吉利碱凝胶剂透皮性能良好，具有明显抑制鳞状细胞癌的作用。
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| 关 键 词： | 农吉利碱 凝胶剂 体外透皮 初步药效学 |
| 收稿时间： | 2013-10-03 |
| 修稿时间： | 2014-02-11 |
Study on Preliminary Pharmacodynamics and Permeation of Monocrotaline Gels in Vitro |
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| ZHOU Minmin,ZHAO Dandan,ZHANG Dejun and HUANG Shengwu. Study on Preliminary Pharmacodynamics and Permeation of Monocrotaline Gels in Vitro[J]. The Chinese Journal of Modern Applied Pharmacy, 2014, 31(8): 968-973 |
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| Authors: | ZHOU Minmin ZHAO Dandan ZHANG Dejun HUANG Shengwu |
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| Affiliation: | Zhejiang Chinese Medical University, Hangzhou 310053, China;Zhejiang Chinese Medical University, Hangzhou 310053, China;Zhejiang Chinese Medical University, Hangzhou 310053, China;Zhejiang Chinese Medical University, Hangzhou 310053, China |
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| Abstract: | OBJECTIVE To study the permeation of monocrotaline gels in vitro and to observe its therapeutic effects of squamous cell carcinoma in mice. METHODS The permeation of monocrotaline gels was measured by using Franz diffusion cell. The therapeutic effects of monocrotaline gels was observed on the model of squamous cell carcinoma in mice. RESULTS The permeation of monocrotaline gels in vitro was very good. The monocrotaline gels could obviously inhibit the squamous cell carcinoma in mice, the tumor inhibitory rate was 35.26%. CONCLUSION The permeation of monocrotaline gels in vitro is very good, the monocrotaline gels can obviously inhibit the squamous cell carcinoma in mices. |
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| Keywords: | monocrotaline gels transdermal in vitro preliminary pharmacodynamics |
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