| Improvement of regional cerebral blood flow after oral intake of ranched-chain amino acids in patients with cirrhosis |
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| 引用本文： | Mika Yamamoto,Motoh Iwasa,Kaname Matsumura,Yuri Nakagawa,Naoki Fujita,Yoshinao Kobayashi,Masahiko Kaito,Kan Takeda,Yukihiko Adachi. Improvement of regional cerebral blood flow after oral intake of ranched-chain amino acids in patients with cirrhosis[J]. World journal of gastroenterology : WJG, 2005, 0(43) |
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| 作者姓名： | Mika Yamamoto Motoh Iwasa Kaname Matsumura Yuri Nakagawa Naoki Fujita Yoshinao Kobayashi Masahiko Kaito Kan Takeda Yukihiko Adachi |
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| 作者单位： | Department of Internal Medicine，Department of Internal Medicine，Department of Radiology，Department of Radiology，Department of Internal Medicine，Department of Internal Medicine，Department of Internal Medicine，Department of Radiology，Department of Internal Medicine Division of Gastroenterology and Hepatology，Mie University School of Medicine，Tsu，Japan，Division of Gastroenterology and Hepatology，Mie University School of Medicine，Tsu，Japan，Mie University School of Medicine，Tsu，Japan，Mie University School of Medicine，Tsu，Japan，Division of Gastroenterology and Hepatology，Mie University School of Medicine，Tsu，Japan，Division of Gastroenterology and Hepatology，Mie University School of Medicine，Tsu，Japan，Division of Gastroenterology and Hepatology，Mie University School of Medicine，Tsu，Japan，Mie University School of Medicine，Tsu，Japan，Division of Gastroenterology and Hepatology，Mie University School of Medicine，Tsu，Japan |
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| 摘 要： | AIM: To evaluate the effect of oral intake of branched-chain amino acids (BCAA) on brain perfusion in patients with liver cirrhosis. METHODS: Single photon emission computed tomography scans were performed in 43 patients with cirrhosis and in 15 age-matched healthy subjects. Twenty-nine out of forty-three patients were randomly treated with either BCAA granules or placebo, and single photon emission computed tomography was performed before and after the treatment. We measured the regional cerebral blood flow values using a three-dimensional stereotaxic region of interest template. RESULTS: Cirrhotic patients had regions of significant hypoperfusion in the bilateral central (right P=0.039, P＜0.05; left P = 0.006 P＜0.01), parietal (right P = 0.018, P＜0.05; left P = 0.009, P＜0.01), angular (right P = 0.039, P＜0.05; left P = 0.008, P＜0.01), and left pericallosal segments (P = 0.038 P＜0.05) as compared with healthy subjects. A significant increase in cerebral perfusion was observed 70 min after the oral intake of BCAA in the angular (right P = 0.012, P＜0.05; left P = 0.049, P＜0.05), temporal (right P=0.012, P＜0.05; left P=0.038, P＜0.05), pericallosal segments (right P=0.025, P＜0.05; left P=0.049, P＜0.05) and left precentral (P = 0.044, P＜0.05), parietal (P = 0.040, P＜0.05) and thalamus (P = 0.033, P＜0.05). No significant change in perfusion was observed in the placebo group. CONCLUSION: Administration of BCAA rapidly improves cerebral perfusion.
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Improvement of regional cerebral blood flow after oral intake of ranched-chain amino acids in patients with cirrhosis |
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| Mika Yamamoto,Motoh Iwasa,Naoki Fujita,Yoshinao Kobayashi,Masahiko Kaito,Yukihiko Adachi. Improvement of regional cerebral blood flow after oral intake of ranched-chain amino acids in patients with cirrhosis[J]. World journal of gastroenterology : WJG, 2005, 0(43) |
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| Authors: | Mika Yamamoto Motoh Iwasa Naoki Fujita Yoshinao Kobayashi Masahiko Kaito Yukihiko Adachi |
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| Affiliation: | Mika Yamamoto,Motoh Iwasa,Naoki Fujita,Yoshinao Kobayashi,Masahiko Kaito,Yukihiko Adachi,Department of Internal Medicine,Division of Gastroenterology and Hepatology,Mie University School of Medicine,Tsu,Japan Kaname Matsumura,Yuri Nakagawa,Kan Takeda,Department of Radiology,Mie University School of Medicine,Tsu,Japan |
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| Abstract: | |
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| Keywords: | Liver cirrhosis Cerebral blood flow Branchedchain amino acids |
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