Early development of cochlear hair cell stereociliary surface morphology |
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Authors: | Sobin Aron Anniko Matti |
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Institution: | (1) Department of Otolaryngology, Karolinska Hospital, S-104 01 Stockholm, Sweden;(2) Otologic Research Laboratories, Karolinska Institute, S-104 01 Stockholm, Sweden |
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Abstract: | Summary The early development of the surface structures of differentiating cochlear hair cells (guinea-pig) was analysed by scanning electron microscopy (SEM). A basal-to-apical gradient was evident in hair cell maturation. Inner hair cells developed before outer hair cells at the same level in the cochlea. The first sign of the onset of hair cell differentiation was a regularization of the pattern of microvilli on the future hair cell. Later, the cluster of regularized microvilli was rebuilt to form the stereociliary bundle, with a stepwise increase in the length of those stereocilia facing the stria vascularis.Supported by grants from Karolinska Institute, the Swedish Medical Research Council (12X-720), the Swedish Society for Medical Sciences and the Foundation Tysta Skolan |
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Keywords: | Inner ear Hair cell Surface structure Stereocilia Cytodifferentiation |
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