| 新疆哈萨克族人群谷胱甘肽S转移酶M1、T1基因多态性 |
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| 引用本文： | 凌敏,安海燕,苟安栓,荣艳,牛灵,白杰.新疆哈萨克族人群谷胱甘肽S转移酶M1、T1基因多态性[J].临床肺科杂志,2012,17(11):1943-1945. |
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| 作者姓名： | 凌敏 安海燕 苟安栓 荣艳 牛灵 白杰 |
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| 作者单位： | 1. 乌鲁木齐,新疆自治区人民医院呼吸二科,新疆,830001
2. 乌鲁木齐,新疆大学研究生院,新疆,830000 |
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| 基金项目： | 中华医学会慢性呼吸道疾病专项基金(2007年) |
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| 摘 要： | 目的 探讨谷胱甘肽S转移酶M1、T1基因多态性在新疆哈萨克族人群中分布的特点.方法通过多重聚合酶链反应对新疆哈萨克族264例个体 GSTM1、GSTT1基因型进行检测.结果 GSTM1、GSTT1基因缺失型在新疆哈萨克族人群中频率分别为47%及36.4%,同时为GSTM1、GSTT1基因缺失型的频率为20.5%.结论 新疆哈萨克族人群GSTM1、GSTT1基因多态性与汉族及其他少数民族存在一定差异.
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| 关 键 词： | 胱甘肽S转移酶 基因型 多态性 |
Frequencies of glutathione S-transferase (GSTs) M1, T1 (GSTM1, GSTT1) polymorphisms in Xinjiang Kazakh population |
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| LING Min
,
AN Hai-yan
,
GOU An-shuan
,
RONG Yan
,
NIU Ling
,
BAI Jie.Frequencies of glutathione S-transferase (GSTs) M1, T1 (GSTM1, GSTT1) polymorphisms in Xinjiang Kazakh population[J].Journal of Clinical Pulmonary Medicine,2012,17(11):1943-1945. |
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| Authors: | LING Min AN Hai-yan GOU An-shuan RONG Yan NIU Ling BAI Jie |
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| Institution: | Department of Respiratory Medicine,People′s Hospital of Xinjiang,Urumqi 830001,China |
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| Abstract: | Objective To investigate the distribution characteristics of glutathione S-transferase(GSTs) M1,T1(GSTM1,GSTT1) polymorphisms in Xinjiang Kazakh population and provide the relevant data for studying the genotype of Kazakh population.Methods GSTM1,GSTT1 genotype of 264 individuals in Xinjiang Kazakh population were detected.Genotype was performed using multiplex polymerase chain react.Results GSTM1-null and GSTT1-null genotype frequencies were respectively 47% and 36.4%,and the frequencies with combination of GSTM1 null and GSTT1 null was 20.5% in Kazakh population.Conclusion There are differences between Xinjiang Kazakh population and the Han and other ethnic minorities in(GSTM1,GSTT1) polymorphisms. |
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| Keywords: | glutathione S-transferase genotype polymorphisms |
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