头孢呋辛酯片的制备及其溶出度研究

目的制备头孢呋辛酯片,并与市售头孢呋辛酯片进行体外溶出度比较。方法采用微晶纤维素、交联聚维酮、微粉硅胶压制成头孢呋辛酯片,分别以pH4.0醋酸盐缓冲液、pH6.8磷酸盐缓冲液、水、0.1mol.L-1盐酸溶液作为溶出介质,用桨法实验,绘制不同溶出介质中的溶出曲线,并计算出相似因子(f2)。结果在4种溶出介质中,自制头孢呋辛酯片和市售头孢呋辛酯片的溶出曲线相似因子(f2)分别为73,68,65和82。结论自制头孢呋辛酯片和市售片的溶出行为一致。

Preparation and in vitrodissolution of Cefuroxime Axetil Tablets

Objective To prepare Cefuroxime Axetil Tablets and to compare the dissolution curves of self-made and market available tablets.Methods Cefuroxime Axetil Tablets were prepared by using microcrystalline cellulose,crosslinking polyvingypyrrolidone and silicon dioxide.Intellectual diffusion meter was used to determine the dissolution curve of market available Cefuroxime Axetil Tablets and self-made tablets.pH4.0 acetate buffer solution,pH6.8 phosphate buffer solution,water and 0.1 mol·L-1 HCl were used as dissolution media.The similarity factors(f2) were calculated in different dissolution media.Results The factors(f2)were 73,68,65 and 82 in pH4.0 acetate buffer solution,pH6.8 phosphate buffer solution,water and 0.1 mol·L-1 HCl,respectively.Conclusion The dissolution profiles of self-made Cefuroxime Axetil Tablets are same as that of market available ones.