慢性阻塞性肺疾病患者氧化应激与肺功能的相关性

目的探讨COPD患者氧化应激状态以及对肺功能的影响。方法选择COPD患者88例,行肺功能测定,根据FEV1%及FEV1/FVC分为轻、中、重三组,并对所有入选者抽取静脉血,化学比色法检测血清还原型谷胱甘肽(GSH)、丙二醛(MDA)、超氧化物歧化酶(SOD)的水平。结果与轻度组比较,中、重度COPD患者SOD、GSH水平明显下降,MDA明显升高(P<0.05、P<0.01)。相关分析显示:MDA与肺功能(FEV1%、FEV1/FVC)呈负相关(P<0.01、P<0.05),SOD、GSH与肺功能呈正相关(P<0.01、P<0.05)。结论 COPD患者体内存在氧化应激失衡,随着氧化/抗氧化功能失衡加重,肺功能下降加剧。

Correlation between oxidative stress and lung function in patients with chronic obstructive pulmonary disease

Objective To detect the status of oxidative stress and their effect on lung function of patients with chronic obstructive pulmonary disease.Methods 88 cases of COPD confirmed by lung function monitoring were selected as three groups,according to FEV1% and FEV1/FVC.All patients were divided into mild,moderate and severe groups.All selected venous blood.MDA,SOD and GSH were monitored by chemical colorimetric.Results The levels of SOD and GSH were significantly decreased in patients with moderate to severe COPD than those in the mild group(P<0.05、P<0.01),and the level of MDA was significantly higher(P<0.05).Correlation analysis showed that SOD and GSH were correlated positively with FEV1% and FEV1/FVC,but MDA on the contrary.Conclusions The oxidative stress is imbalance in COPD patients,and with the function of oxidant/antioxidant imbalance increasedly,lung function declines intensely.