T2毒素对大鼠红细胞膜脂流动性及脂质过氧化的影响 |
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引用本文: | 彭双清 杨进生. T2毒素对大鼠红细胞膜脂流动性及脂质过氧化的影响[J]. 中国药理学与毒理学杂志, 1994, 8(3): 239-240 |
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作者姓名: | 彭双清 杨进生 |
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作者单位: | 北京毒物药物研究所 |
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摘 要: | T2毒素对大鼠红细胞膜脂流动性及脂质过氧化的影响彭双清,杨进生(北京毒物药物研究所,北京100850)T2毒素是倍半萜类两歧性分子,极易与膜发生作用[1].它能抑制DNA,RNA和蛋白质的合成,引起DNA单链断裂及多核蛋白体分裂,以及与巯基酶相结合[...
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关 键 词: | 真菌毒素类;毒素,T2;红细胞膜;膜流动性;脂质过氧化 |
Effect of T2 toxin on lipid fluidity and peroxidation of erythrocyte membrane of rats |
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Abstract: | In the present investigation,thechange of lipid fluidity andperoxidadon of raterythrocyte membrane treated with the trichothecenemvcotoxin T2 in vitro were examinel The results show-ed that T2 toxin had dose and time一detpendent effectson lipid fluidity of erythrocyte membrane。At T2 toxindoses of 1.0 and 10.0 mg·L-1 the membrane lipid flu-idity increased with the incubation time,at 100.0 mg·L-1,the highest dose tested,during the first 5 h,themembrane lipid fluidity increased,but then after 5 h,Feturned to the control level.In the tested doses of 5、0and 100.0mg·L-1,T2 toxin did not induced changeof concentration of membrane lipid peroxides.Thechange of erythrocyte membrane flexibility was one ofthe expression parameters of membrane injury inducedby T2 toxin。this change may be caused by T2 toxin in-teracting directly with the erythrocyte membrane。 |
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Keywords: | mycotoxins toxin T2 erythrocytemembrane membrane fluidity lipid peroxidation |
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