妊高征患者胎盘床滋养细胞内皮素(ET-1)的表达与临床意义

目的:观察妊高征患者胎盘床浸润的滋养细胞内皮素(ET-1)的表达情况,探讨妊高征的发病机理。方法:收集正常妊娠病例30例,妊高征共70例,其中轻度30例,中度20例,重度20例,用免疫组化方法对妊高征和正常妊娠的胎盘床蜕膜段和肌层浸润的滋养细胞进行ET-1的标记。结果:ET-1在妊高征胎盘床蜕膜段浸润的滋养细胞的表达与正常妊娠无明显差别(P>0.05),ET-1在妊高征胎盘床肌层浸润的滋养细胞的表达明显高于正常妊娠(P<0.05)。讨论:妊高征时胎盘床肌层浸润的滋养细胞分泌的内皮素明显增多,提示妊高征的发生可能与肌层浸润的滋养细胞分泌的内皮素增多有关。

The Expression of ET - 1 in Trophoblasts of Placental Bed in Pregrancy With Preeclapsia and Clinical Significance

Objective:The expression of ET-1 in trophoblasts of placental bed in pregrancy with pre-eclampsia to explore the pathogenesis of pre-eclampsia.Methods:30 cases of normal pregnancy were investigated in control group,70 cases of pre-eclampsia were investigated in study group,including 30 cases of mild pre-eclampsia,30 cases of mediterate pre-eclampsia,20 cases of severe pre-eclampsia,immunohistochemical technique was used to mark the ET-1 in trophoblasts infiltrating desidual-placental bed and myo-placental bed in normal pregrancy and pre-eclampsia.Results:There are no significant difference of expression of ET-1 in trophoblasts infiltrating decidual-placental bed between normal pregrancy and Pre-eclampsia(P>0.05).The expression of ET-1 in trophoblasts infiltrating myo-placental bed of pre-eclampsia is higher than normal pregnancy(P<0.05).Conclusion:The secretion of ET-1 in trophoblasts infiltrating myo-placental bed is significantly increased in pre-eclampsia,which indicate that the increase of ET-1 might play an important role in the development of pre-eclampsia.