| NF-1在瘢痕疙瘩中表达的研究 |
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| 引用本文： | 王惠东,郑江红,邓辰亮,宋楠,吴娟娟,张世新,丁志,茅广宇,葛岚,赵喜彬,杨松林.NF-1在瘢痕疙瘩中表达的研究[J].中国美容医学,2009,18(4):497-499. |
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| 作者姓名： | 王惠东 郑江红 邓辰亮 宋楠 吴娟娟 张世新 丁志 茅广宇 葛岚 赵喜彬 杨松林 |
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| 作者单位： | 1. 上海交通大学附属第六人民医院整形科,上海,200233
2. 上海交通大学附属第九人民医院上海组织工程中心,上海,200011 |
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| 摘 要： | 目的：通过比较人瘢痕疙瘩与正常皮肤组织中NF-1（nulear factor 1）在mRNA水平的表达量，来研究该基因在瘢痕疙瘩中发生的变化，并探讨其意义。方法：收集了3例正常皮肤标本和3例瘢痕疙瘩标本，用荧光定量PCR分别检测两种组织中NF-1在mRNA水平的表达量。结果：正常皮肤组和瘢痕疙瘩组中NF-1在mRNA水平的表达差异显著（P〈0．05），正常皮肤组中NF-1的表达量是瘢痕疙瘩组的35倍。结论：NF-1 mRNA的高表达可能与瘢痕疙瘩疙瘩的发生相关，具体机制尚需进一步研究。
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| 关 键 词： | 瘢痕疙瘩 转录因子 NF-1 |
Study of NF-1 Expression in Keloid |
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| WANG Hui-dong,ZHENG Jiang-hong,DENG Chen-liang,SONG Nan,WU Juan-juan,ZHANG Shi-xin,DING Zhi,MAO Guang-yu,GE Lan,ZHAO Xi-bin,YANG Song-lin.Study of NF-1 Expression in Keloid[J].Chinese Journal of Aesthetic Medicine,2009,18(4):497-499. |
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| Authors: | WANG Hui-dong ZHENG Jiang-hong DENG Chen-liang SONG Nan WU Juan-juan ZHANG Shi-xin DING Zhi MAO Guang-yu GE Lan ZHAO Xi-bin YANG Song-lin |
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| Institution: | 1.Department of Plastic Surgery;the 6th People's Hospital;Shanghai Jiaotong University;Shanghai 200233;China;2.The Tissue Engineering Center of Shanghai;the 9th People's Hospital;Shanghai 200011;China |
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| Abstract: | Objective To investigate the changes and significance of NF-1 expression based on the comparison of NF-1 mRNA expression between keloid and normal skin tissue.Methods Keloid and normal skin tissues were collected,then NF-1 mRNA expression in keloid and normal skin tissues were detected respectively with realtime qualitative PCR.Results The difference of NF-1 mRNA expression between keloid group and normal skin group is statistically significant(P<0.05),the NF-1 mRNA expression in keloid group is 35 times hi... |
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| Keywords: | NF-1 |
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