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Promotion of skin tumours by TPA in the progeny of mice exposed pre-natally to DMBA |
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| Authors: | Napalkov N; Likhachev A; Anisimov V; Lokitonov A; Zabezhinski M; Ovsyannikov A; Wahrendorf J; Becher H; Tomatis L |
| Institution: | N.N.Petrov Research Institute of Oncology 68 Leningradskaya St, Pesochny-2, 188646 Leningrad, USSR 1International Agency for Research on Cancer 150 cours Albert-Thomas, 69372 Lyon Cedex 08, France 3Present address:Department of Epidemiology, Institute of Documentation, Information and Statistics German Cancer Research Center, Im Neuenheimer Feld 280, 6900 Heidelberg, FRG 2Institut für Präventionsforschung und Sozialmedizin Präsident Kennedy-Platz 1, 2800 Bremen, FRG |
| Abstract: | Pregnant SHR mice were treated once with 7,12-dimethyl-benza]anthracene(DMBA) on day 17–19 of gestation, and F1 and F2 descendantsreceived multiple skin applications of 12-O-tetradecanoylphorbol-13-acetate(TPA) twice a week for 24 weeks beginning at 12 weeks of age.Post-natal promoter treatment resulted in a high incidence ofskin twmours in F1 and F2 mice (37.3 and 19.7%, respectively),whereas only 6.6% of control animals treated with TPA only developedskin tumours. DMBA was shown previously to be capable of initiating skin carcinogenesis transplacentally; however, ourresults on the second generation provide suggestive evidenceof hereditary transmission of at least part of the initiatingaction of this carcinogen. |
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