骨骼肌源性因子与胰岛素抵抗的研究进展

过去十年间(2002²013),骨骼肌被看作是人体内最大的内分泌器官,骨骼肌肌纤维可以分泌产生释放一些细胞因子类和肽类物质发挥内分泌、旁分泌和自分泌作用。这些细胞因子类和肽类物质被定义为骨骼肌源性因子,作用于其他器官和组织,如脂肪组织、肝脏、胰腺、骨和大脑等发挥调节神经、内分泌和免疫系统等生物学效应。近年来研究发现胰岛素抵抗(IR)的产生与骨骼肌源性因子的异常分泌有关,而身体缺乏运动会导致骨骼肌因子应答改变,这一个机制可能用于解释骨骼肌源性因子与IR的关系。

Research Development of Myokines and Insulin Resistance

During the past decade（2002-2013）,skeletal muscle has been identified as the biggest secretory organ.Accordingly,we have suggested that cytokines and other peptides that are produced,expressed and released by muscle fiberes and exert either autocrine,paracrine or endocrine effects should be classified as myokines.The finding that the muscle secretome consists of several hundreds secreted peptides provides a conceptual basis and a whole new paradigm for understanding how muscles communicate with other organs,such as adipose tissue,liver,pancreas,bones and brain.Recent studies have found that abnormal myokines are related to insulin resistance（IR）,and physical inactivity probably leads to an altered myokine response,which could provide a potential mechanism for explaining the association between sedentmy myokines and IR.