新诊断2型糖尿病抑郁症的患病率及独立危险因素分析

目的调查新诊断2型糖尿病患者抑郁症的患病率，探讨与抑郁相关的危险因素。方法对南海区人民医院内分泌代谢科2010年2月～2012年2月新诊断的545例2型糖尿病患者，应用Beck抑郁问卷（BDI）进行抑郁评分并分组，收集年龄、性别、月收入、吸咽史、糖化血红蛋白（HbA圯）、C肽水平、三酰甘油（TG）、低密度脂蛋白胆固醇（LDL-C）、尿微量白蛋白／肌酐及糖尿病周围神经病变（DPN）发生率资料，计算抑郁症的患病率，采用Logistic回归筛选与抑郁相关的危险因素。结果新诊断2型糖尿病抑郁症的患病率为37．8％。女性，低年龄，高HbAm低C肽水平，血脂代谢紊乱，诊断时合并糖尿病肾病及糖尿病周围神经病变的患者发生抑郁症风险较高。其中女性，年龄，HbA_1C、C肽水平、尿微量白蛋白／肌酐、DPN为抑郁症的独立危险因素。结论新诊断2型糖尿病患者抑郁症患病率较高，诊疗时应及早筛查，及时干预。存在抑郁危险因素的患者，建议定期随访。

Analysis of prevalence of depression for patients newly diagnosed with type 2 diabetes and its independent risk factors.

Objective To investigate the prevalence of depression and its risk factors associated with depression for patients newly diagnosed with type 2 diabetes. Methods Beck Depression Inventory （BDI） was used to quantied de- pression in 545 newly diagnosed type 2 diabetic patients in Nanhai people＇s hospital from February 2010 to February 2012 and all patients were divided into groups according the depression scores. The demographical character and dia- betes-related data （age, gender, economic status, smoking, HbAlc, C-peptide, TG, LDL-C, urine microalbuminuria/ creatinine and incidence rate of DPN） were collected and prevalence of depression was calculated. The independent risk factors associated with depression were screened by stepwise Logistic regression. Results 37.8% patients newly diagnosed with type 2 diabetes had trend of depression. Patients featured with female, low age, high level of HbAic, low level of C-peptide, lipid disorder, complacated by diabetic nephropathy and DPN might beat a higher risk of de- pression. The independent risk factors associated with depression were female, age, HbAic, C-peptide, urine microal- buminuria/creatinine and incidence rate of DPN. Conclusion It has higher prevalence of depression for patients newly diagnosed with type 2 diabetes and the screening and intervention should be developed as soon as possible. The patients with independent risk factors of deoression are necessarv to follow up.