| 阿莫西林中高分子杂质的测定与质量分析 |
| |
| 引用本文： | 李哲媛, 李玉凤, 范兵, 向金莲. 阿莫西林中高分子杂质的测定与质量分析[J]. 中国现代应用药学, 2006, (4): 326-327. |
| |
| 作者姓名： | 李哲媛 李玉凤 范兵 向金莲 |
| |
| 作者单位： | 云南省药品检验所,昆明,650011 |
| |
| 摘 要： | 目的比较不同厂家阿莫西林原料、胶囊、混悬剂中高分子杂质的含量。方法采用OhpakSB-802.5HQ(聚合基柱)高效液相凝胶色谱系统进行分离分析。结果21批阿莫西林样品中高分子杂质的测定结果均为1%以下。结论国产与进口阿莫西林中的高分子杂质含量无显著差异。
|
| 关 键 词： | 阿莫西林 高分子杂质 凝胶色谱 |
| 文章编号： | 1007-7693（2006）04-0326-02 |
| 收稿时间： | 2005-03-14 |
| 修稿时间： | 2005-03-14 |
Studies on the separation and quality of high molecular weight impurities in amoxicillin |
| |
| LI Zhe-yuan, LI Yu-feng, FAN Bing, XIANG Jin-lian. Studies on the separation and quality of high molecular weight impurities in amoxicillin[J]. Chinese Journal of Modern Applied Pharmacy, 2006, (4): 326-327. |
| |
| Authors: | LI Zhe-yuan LI Yu-feng FAN Bing XIANG Jin-lian |
| |
| Affiliation: | Yunnan Institute for Drug Control ,Kunming 650011, China |
| |
| Abstract: | OBJECTIVE To develop a method for determination the high molecular impurities in amoxieillin to evaluate the quality of amoxieillin and its capsule or suspension. METHODS Determination of high molecular impurities using Ohpak SB-802.5HQ gel filtration chromatography was established. RESULTS 21 batehas of amoxieillin were analyzed. The contents of the high molecular impurities were all less than 1%. CONCLUSION Results of analysis showed there were no significant differents in the contents of impurities between domestic and imported. |
| |
| Keywords: | amoxieillin high molecular impurities gel filtration chromatography |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《中国现代应用药学》浏览原始摘要信息 |
|
点击此处可从《中国现代应用药学》下载全文 |
