妊娠糖尿病胰岛素抵抗的研究进展

胰岛素抵抗综合征(X综合征)包括糖耐量减退或糖尿病、高胰岛素血症、高血压、肥胖、高血脂、冠状动脉粥样硬化性心脏病、痛风等,妊娠糖尿病应包括在胰岛素抵抗综合征之中。妊娠糖尿病的发病机制不完全清楚,目前一致的观点认为:妊娠糖尿病患者存在胰岛β细胞功能缺陷和胰岛素抵抗。大量研究表明,脂肪细胞因子:肿瘤坏死因子、瘦素、脂联素和抵抗素等也参与了妊娠糖尿病胰岛素抵抗的发生和发展。

Study Progress of Insulin Resistance in Gestational Diabetes Mellitus

Insulin resistance syndrome (syndrome X) includes impaired glucose tolerance,diabetes mellitus,hyperinsulinemia,hypertension,obese,dyslipidemia,coronary artery disease,gout and so on.Gestational diabetes is also included in them,of which the pathogenesis is not very clear.The corresponding view is that there is functional defect of beta cell of islet and insulin resistance in gestational diabetes.Quantity of studies showed that adipocytokines participated in the genesis and development of insulin resistance in gestational diabetes including TNF-α,Leptin,adiponection,resistin and so on.