| 3-乙酰乌头碱的毒性和致畸性 |
| |
| 引用本文： | 陈丽娟,唐希灿,王美瑛,孙伟康,刘明章.3-乙酰乌头碱的毒性和致畸性[J].中国药理学与毒理学杂志,1987(1). |
| |
| 作者姓名： | 陈丽娟 唐希灿 王美瑛 孙伟康 刘明章 |
| |
| 作者单位： | 中国科学院上海药物研究所，中国科学院上海药物研究所，中国科学院上海药物研究所，中国科学院上海药物研究所，中国科学院上海药物研究所 上海 200031，上海 200031，上海 200031，上海 200031，上海 200031 |
| |
| 摘 要： | 小鼠ig 3-乙酰乌头碱的LD_(50)为3.09mg/kg,其他各种注射途径的LD_(50)在0.40-0.70mg/kg间,约为ig的13-23％;大鼠LD_(50)为小鼠的53-74％。在亚急性毒性实验中,3-乙酰乌头碱中毒剂量可致大鼠呼吸抑制而死亡,家兔除有呼吸抑制外尚出现ECG的异常。组织病理学变化主要为心肌细胞变性,肝细胞轻度损伤。阿托品加人工呼吸对3-乙酰乌头碱所致的大鼠和兔的呼吸抑制有较好的对抗效果。致畸实验未见胎仔畸形。
|
| 关 键 词： | 3-乙酰乌头碱 急性毒性 亚急性毒性 致畸性 心肌细胞变性 |
The toxicity and the teratogenicity 3-acetylaconitine |
| |
| CHEN Li-juan,TANG Xi-can,WANG Mei-ying,SUN Wei-kang,LIU Ming-zhang.The toxicity and the teratogenicity 3-acetylaconitine[J].Chinese Journal of Pharmacology and Toxicology,1987(1). |
| |
| Authors: | CHEN Li-juan TANG Xi-can WANG Mei-ying SUN Wei-kang LIU Ming-zhang |
| |
| Abstract: | 3-Acetylaconitine(AAC) is a new alkaloid isolated from Aconitum flavum. Its acute ig LD50 was 3.09 mg/kg in mice, while the LD50 of the drug administered by other routes were 13-23 percent of ig LD50. In subacute experiments, the main toxic manifestations of AAC were respiratory depression which usually caused death in rats and abnormal ECG in rabbits. In histo-pathological examinations all of the animals treated with AAC showed degenerative change in heart muscle cells and slight damage in livercells. It has been found that atropine plus artificial respiration were effective in increasing survival number of intoxicated rabbits. No teratogenic effect of AAC was observed on mice or rabbits. In the positive control with cod-liver oil extract a lot of external malformations and cleft palate in the fetuses of mous had been found. |
| |
| Keywords: | 3-acetylaconitine acute toxicity subacute toxicity teratogenicity cardiomyocytc degeneration |
| 本文献已被 CNKI 等数据库收录！ |
