The ventilatory-perfusion imbalance in the lung after burns complicated with acute major blood loss — a dog study

Summary The study presented investigates indices of central and regional pulmonary function in dogs after combined trauma (5% full thickness thermal burn with acute blood loss) and during blood transfusion by the intraosteal pumping method. The combined trauma resulted in 100% death of dogs within the first three hours after the injury. Blood reinfusion causes a short-lived beneficial effect. With a relative stabilisation of central hemodynamics pulmonary perfusion decreased to 63% of its initial value. The lung tissue blood filling increased to 158% with a decrease of pulmonary air content to 55.8%, this indicated an initial process of liquid blood parts penetrating into the interstitial space and pulmonary alveoli, which resulted in 65% death of dogs.Correspondence to: Dr. AN. Belyaev