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Case report: Long-standing complex regional pain syndrome relieved by a cephalosporin antibiotic |
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| Authors: | Mark A. Ware Gary J. Bennett |
| Affiliation: | 1. The Alan Edwards Pain Management Unit, McGill University Health Centre, McGill University, Montreal, Quebec, Canada;2. Department of Family Medicine, McGill University, Montreal, Quebec, Canada;3. Department of Anesthesia, McGill University, Montreal, Quebec, Canada;4. Faculty of Dentistry, McGill University, Montreal, Quebec, Canada;5. The Louise and Alan Edwards Centre for Research on Pain, McGill University, Montreal, Quebec, Canada |
| Abstract: | We describe a young woman who had had treatment-refractory complex regional pain syndrome (CRPS) for 6 years before receiving antibiotic treatment with cefadroxil (a cephalosporin derivative) for a minor infection. Cefadroxil reduced the patient’s pain and motor dysfunction (dystonia and impaired voluntary movement) within days; the pain and motor disorder returned when cefadroxil was discontinued; and both again abated when cefadroxil was re-instituted. The patient has now had symptom relief for more than 3 years on continuing cefadroxil therapy. We discuss this case in the context of previous reports of antibiotic treatment relieving neuropathic pain in experimental animals. |
| Keywords: | Cefadroxil Ceftriaxone Cephalosporin CRPS RSD Neuropathic pain |
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