A new synthetic 2′-hydroxy-2,4,6-trimethoxy-5′,6′-naphthochalcone induces G2/M cell cycle arrest and apoptosis by disrupting the microtubular network of human colon cancer cells |
| |
Authors: | Jong Min Lee Mi So Lee Dongsoo Koh Young Han Lee Yoongho Lim Soon Young Shin |
| |
Affiliation: | 1. Department of Biological Sciences, College of Biological Science and Biotechnology, Cancer and Metabolism Institute, Konkuk University, Seoul 143-701, Republic of Korea;2. Department of Applied Chemistry, Dongduk Women''s University, Seoul 136-714, Republic of Korea;3. Division of Bioscience and Biotechnology, BMIC, Konkuk University, Seoul 143-701, Republic of Korea |
| |
Abstract: | Methoxylated chalcones exert antitumor activities. In the present study, we characterized the cytotoxicity of methylated chalcone derivatives against human colon cancer cells. We synthesized a group of methoxychalcones and explored the molecular mechanisms underlying inhibition of tumor growth by these materials. A new synthetic methoxychalcone, 2′-hydroxy-2,4,6-trimethoxy-5′,6′-naphthochalcone (named HMNC-74), most effectively inhibited the clonogenicity of SW620 colon cancer cells. Mechanistically, HMNC-74 triggered cell cycle arrest at G2/M phase, followed by an increase in apoptotic cell death. Our results indicate that the cytotoxicity of the novel compound HMNC-74 involves the disruption of microtubular networks. |
| |
Keywords: | 2&prime -Hydroxy-2,4,6-trimethoxy-5&prime ,6&prime -naphthochalcone Tubulin polymerization G2/M arrest Apoptosis Caspase-2 |
本文献已被 ScienceDirect 等数据库收录! |
|