| 卡铂栓剂的稳定性研究 |
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| 引用本文： | 陈启蒙,李薇,刘照胜,陈涓. 卡铂栓剂的稳定性研究[J]. 中国药学杂志, 2000, 35(3): 168-171 |
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| 作者姓名： | 陈启蒙 李薇 刘照胜 陈涓 |
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| 作者单位： | 天津医科大学,天津,300203 |
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| 摘 要： | 目的：时新研制的卡铂栓进行稳定性实验研究.方法：通过影响因素，加速和自然留样实验，采用HPLC测定卡铂栓的含量和降解产物，并观察外观性状变化，结果：卡铂栓剂为脂溶性基质时，室温光照高湿度条件包装情况下稳定性好。结论：本方法测定快速、简便、准确，表明卡铂栓应于避光干燥，25℃以下保存。
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| 关 键 词： | 卡铂 栓剂 稳定性 HPLC |
| 收稿时间： | 1999-09-09; |
The stability of carboplatin suppository |
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| Chen Qimeng. The stability of carboplatin suppository[J]. Chinese Pharmaceutical Journal, 2000, 35(3): 168-171 |
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| Authors: | Chen Qimeng |
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| Affiliation: | (Chen QM),Li Wei (Li W),Liu Zhaosheng (Liu ZS |
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| Abstract: | OBJECTIVE:To study the stability of carboplatin suppository.METHODS: HPLC was used to determine the carboplatin in the carboplatin suppository samples under the conditions of severe test,accelerated test and longterm storage test.The variations of the appearance and propertise was observed.RESULTS:In lipid suppository base,the carboplatin was stability at room temperature,light and high humidity conditions.CONCLUSION: The assay is accurate,rapid and sensitive.The carboplatin suppository stability was good if stored it under 25℃ and dry place. |
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| Keywords: | carboplatin suppository stability HPLC |
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