南昌地区献血人群幽门螺杆菌感染的血清学分析

目的调查南昌地区献血人群中幽门螺杆菌（Up）感染的血清阳性率并对其影响因素进行分析。监控HD在献血不同人群中感染变化规律，为优化献血人群作参考。方法采用整群抽样方式抽取2010年6-9月南昌地区不同献血种类（全血和机采血小板）的献血者633人（男377人，女256人）。采取统一调查表进行现场问卷调查方式，采用ELLSA检测血清中Hp-IgG抗体，数据统计分析采用SPSS17．0软件。结果献血人群总的Hp感染血清阳性率为48．66％（308／633）。男女之间、不同ABO血型间Hp阳性率差异无统计学意义（P〉0．05）：不同年龄、婚姻状况、体重指数、医务人员与非医务人员间的Hp阳性率差异有统计学意义（P〈0．05）；逐步多因素Logistic回归分析筛选出与Hp感染相关的凶素分别为共同居住人数（OR=1．394，X^2=4．675，P=0．031），就餐规律性（OR=0．650，X^2=10．902，P=0．001）、吸炯（OR=0．631，X^2=6．432，P=0．011）、机采血小板献血者（OR=0．731．X^2=9．205，P=0．002）和AB血型（OR=0．512，X^2=3．995，P=0．046）。结论南昌地区献血人群中存在较高的Hp感染血清阳性率；Hp感染与同居住人数多少、是否吸炯、就餐规律性等相关联：AB型血相比A型、B型和0型不易感染Hp；机采血小板献血人群中Hp感染率较低；Hp阳性率在献血人群中的情况分布及影响因素的分析埘于完善献血标准、对了解南昌地区的献血队伍提供了参考数据。

Seroprevalence study on Helicobacter pylori infection among volunteer blood donors in Nanchang

Objective To evaluate the seropositive rate of antibodies against Helicobacter pylori （Hp） and to study Hp infection situation and the influential factors of Hp infection among volunteer blood donors in Nanchang. Methods 633 healthy volunteer blood donors 377 males, 256 females, mean age （30.3±9.1） years, range 18-54 years, from June to September in 2010] were enrolled in the study. The questionnaire was designed to acquire related information. Demographic data recorded for each donor included gender, age, occupation, marital status and life styles and so on. The blood sampleswere was collected and anti-Hp （IgG） antibodies of the serum were detected by double-antibody sandwich enzyme-linked immunosorbent assay （ELISA）. Data analysis was done by using SPSS version 17.0 statistical package. Results The overall seroprevalence of Hp infection in voulunteer blood donors was 48.66% （308/633）. The prevalenees of anti-Hp antibody were no significant difference in males compared to females （P 〉 0.05）; the results of simple Lo- gistic regression showed that factors with significant ORs were young age, unmarried, slim body, number of people living together, not smoking, eating irregularly and medical personnel （P 〈 0.05）; the results of stepwise Logistic regression showed that factors entered regression model were number of people living together （OR = 1.394, X^2=4.675, P = 0.031）, eating regularly （OR = 0.650, X^2=10.902, P = 0.001）, smoking （OR = 0.631, X^2=6.432, P = 0.011）, dedicate a blood platelets （OR = 0.731, X^2=9.205, P = 0.002） and group AB （OR = 0.512, X^2=3.995, P = 0.046）. Conclusion Helicobac- ter pylori seroprevalenee rates are high among the volunteer blood donors in Nanchang. Hp infection Can be related to age, occupation, marital status, BMI, smoking, number of people living together and eating regulation. Blood group A and B is not a risk factor for acquiring Hp infection; the prevalence of anti-Hp lgG antibody of blood platelets dedication is lower compare to the whole bh）od donation. Hp seroprevalence in the distribution of t）lood donors provides a reference for improving the blood donation criteria and a reasonable choice of blood donors in Nanchang.