慢性阻塞性肺疾病患者血清白介素18、C反应蛋白与生活质量及肺功能的相关性

目的探讨慢性阻塞性肺疾病（COPD）患者血清白介素18（IL-18）及C反应蛋白（CRP）与生活质量及肺功能的相关性。方法选取沈阳医学院奉天医院2011年10月～2012年10月收治46例COPD患者为研究对象，分为慢性阻塞性肺疾病急性发作期（AECOPD）组26例和COPD组20例，选取同期健康体检者25例为对照组，检测三组患者的血清IL-18及CRP。并评定三组患者的SGRQ评分，测定AECOPD组和COPD组患者的肺功能。结果AECOPD组患者的血清IL-18及CRP显著高于COPD组及对照组，COPD组患者的血清IL-18及CRP显著高于对照组，三组间比较，差异有统计学意义（P〈0．05）。AECOPD组患者的SGRQ评分显著高于COPD组及对照组，COPD组患者的SGRQ评分显著高于对照组，三组间比较，差异有统计学意义（P〈0．05）。AECOPD组和COPD组患者的血清IL-18及CRP与肺功能呈负相关。AECOPD组和COPD组患者的血清IL-18及CRP与SGRQ评分呈正相关。结论血清IL-18及CRP与COPD患者的肺功能和生活质量有关，且可作为判断COPD急性加重期的指标，值得临床推广应用。

Correlation of serum IL-18 and CRP and associated with the quality of life and lung function in chronic obstructive pulmonary disease patients

Objective To explore the correlation of serum iL-18 and CRP and associated with the quality of life and lung function in chronic obstructive pulmonary disease patients. Methods 46 patients of chronic obstructive pulmonary disease （COPD） patients were selected as the research object in our hospital from October 2011 to October 2012, they were divided into AECOPD group of 26 cases and COPD group of 20 cases, 25 cases health physical examination person were selected at the same period as control group, three groups of patients with serum IL-18 and CRP on admission were detected and the three groups of patients with SGRQ grading were evaluated, the pulmonary function AECOPD group and COPD group were measured. Results The serum IL-18 and CRP in AECOPD group were significantly higher than those of COPD group, the serum IL-18 and CRP in COPD group were significantly higher than those of control group, the difference was statistically significant among the three groups （P 〈 0.05）. The SGRQ score in AECOPD groups was significantly higher than that of COPD group and control group, the SGRQ score in COPD patients was significantly higher than that of the control group, the difference was statistically significant among the three groups （P 〈 0.05）. The serum IL-18 and CRP in AECOPD group and COPD group were negatively correlated with the lung function. The serum IL-18 and CRP in AECOPD group and COPD group were positive correlation with the SGRQ score. Conclusion The serum IL-18 and CRP are associated with COPD patients with pulmonary function and the quality of life, and they can be used as judgment COPD exacerhations issue of the index, it is worth clinical application.