| 葡萄籽中原花青素灌胃及注射给药的抗炎作用和刺激性 |
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| 引用本文： | 雷洁琼,张惠春,李文广.葡萄籽中原花青素灌胃及注射给药的抗炎作用和刺激性[J].兰州医学院学报,2008,34(1):33-35. |
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| 作者姓名： | 雷洁琼 张惠春 李文广 |
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| 作者单位： | [1]甘肃省肿瘤医院内科,甘肃兰州730050 [2]甘肃靖远煤业公司总医院中医科,甘肃白银730913 [3]兰州大学药学院,甘肃兰州730000 |
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| 摘 要： | 目的 研究葡萄籽中原花青素(proanthocyanidins,PA)灌胃给药的抗炎作用及注射给药的刺激性.方法 用巴豆油诱导的小鼠耳肿和角叉菜胶诱导的大鼠足肿模型,观察原花青素灌胃给药的抗炎作用,并观察原花青素肌肉和腹腔注射的刺激性.结果 PA 40 mg/kg单次腹腔注射能明显抑制角叉菜胶诱导的大鼠足肿和巴豆油诱导的小鼠耳肿,而PA 200～400 mg/kg单次或多次灌胃给药对角叉菜胶诱导的大鼠足肿和巴豆油诱导的小鼠耳肿均无明显影响,但给药期间小鼠和大鼠均未见明显异常反应;PA 40 mg/kg腹腔注射后小鼠活动减少、蜷缩,部分小鼠出现扭体反应,肌肉注射24 h后给药部位有渗出液、充血、组织坏死等反应,说明PA腹腔和肌肉注射有刺激性.结论 葡萄籽中原花青素灌胃给药无明显的抗炎作用,而注射给药有一定的刺激性.
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| 关 键 词： | 原花青素 葡萄籽 炎症 刺激性 |
| 文章编号： | 1000-2812(2008)01-0033-03 |
| 修稿时间： | 2007年9月12日 |
Anti-inflammatory effects of procyanidin from grape seeds by intragastric and injective administrations |
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| LEI Jie-qiong ZHANG Hui-chun LI Wen-guang.Anti-inflammatory effects of procyanidin from grape seeds by intragastric and injective administrations[J].Journal of Lanzhou Medical College,2008,34(1):33-35. |
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| Authors: | LEI Jie-qiong ZHANG Hui-chun LI Wen-guang |
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| Institution: | LEI~1 Jie-qiong~1 ZHANG Hui-chun~2 LI Wen-guang~3 (1.Department of Internal Medicine,the Cancer Hospital of Gansu Province,Lanzhou 730050,China,2.Department of Traditional Chinese Medicine,The General Hospital of Gansu Jingyuan Coal lndustry Company,Baiyin 730913,Gansu,3.School of Pharmacy,Lanzhou University,Lanzhou 730000,China) |
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| Abstract: | Objective To study the anti-inflammatory effects of procyanidin (PA) from grape seeds by intragastric and injective administrations.Methods Croton oil-induced ear swelling model of mice and carrageenan-induced hind paw edema model of rats were established,and the anti-inflammatory effects of PA were investigated by intragastric while its injective irritation was investigated by muscular and intraperitoneal injections.Results PA 40 mg/kg peritoneal injec- tion once significantly inhibited carrageenan-induced... |
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| Keywords: | procyanidin grape seeds inflammation irritation |
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