小儿哮喘急性发作的病原学研究

目的 :探讨重庆地区小儿哮喘急性发作与呼吸道病毒及肺炎支原体 (MP)、肺炎衣原体 (CP)感染的相关性。方法 :采取患儿鼻咽分泌物用免疫荧光快速诊断方法检测包括呼吸道合胞病毒 (RSV)、腺病毒 (Adv)、流感病毒A、B(InfA、B)型、副流感病毒 1、2、3(PInf1、2、3)型在内的 7种病毒抗原及血清ELISA法检测CP、MPIgM抗体。结果 :4 5例婴幼儿哮喘患儿阳性检出有 18例 (40 % )其中感染RSV有 13例 (2 8.9% )居首位 ,其次为CP有 3例 (6 .7% ) ,MP有 1例 (2 .2 % ) ,PInf3有 1例 (2 .2 % )。 37例儿童哮喘阳性检出有 13例 (35 .1% )其中感染MP有 9例 (2 4 .3% )居首位 ,其次为RSV有 4例 (10 .8% ) ,其余均阴性。结论 :RSV及CP感染与婴幼儿哮喘急性发作关系密切 ,而MP感染与儿童期哮喘急性发作关系密切。

Study on the clinical etiology of acute attack of asthma in children

Objective:To explore the relationship between viral respiratory tract,mycoplasmal pneumonia,Chlamydia pneumonia infection and actue attack of asthma in children.Methods:7 viruses including respiratory syncytial virus(RSV),adenovirus(Adv),influenza virus A(InfA),influenza virusB(InfB),and parainfluenza virus 1.2.3(PInfl.2.3) from the nasopharyngeal aspirate of the patients were rapidly diagnosed by immunofluorescence method and MP.CP-IgM in serum were detected with ELISA.Results:18 cases could reach the definite etiological diagnosis among 45 infant asthmatic patients (40%).Of them RSV was discovered in 13 cases (accounting for 28.9%),ranking the first,second CP in 3 cases (6.7%),MP in 1 case (2.2%) and Plnf3 in 1 case (2.2%).13 cases (35.1%) were detected positively in 37 asthmatic patients of children.Of them MP was discovered in 9 cases (24.3%),ranking the first,second RSV in 4 cases (10.8%).Conclusion:The results indicate that infant asthma exacerbation is related closely to RSV and CP infections,but in children acute asthma exacerbation is related closely to MP infection.