循证医学在脓毒症临床试验中的应用

循证医学已广泛应用于脓毒症研究领域，对脓毒症临床试验产生了积极的推动作用和重要影响。在进行脓毒症临床试验设计的过程中，应注意样本选择、观察指标和亚群分析等。采用循证医学方法对脓毒症临床试验性治疗措施进行评估，产生了几项具有较高可信度的临床研究报告，包括人体活化蛋白C抗凝治疗、严格控制血糖、糖皮质激素治疗等。

Application of evidence-based medicine in evaluation of clinical trials in sepsis

Evidence-based medicine is also currently promoted and extolled as the best way to evaluate its various treatment and to draft clinical guidelines for the management of severe sepsis with aim to result in a reduction in mortality. There are several obvious factors in the design and conduct of clinical trials in sepsis to be observed, including case selection, end points, and sub-population evaluation, etc. In the past years, several scientific reports of evidence-based strategies for the treatment of sepsis were published, including recombinant human activated protein C, control of hyperglycemia in sepsis, and administration of low dose of corticosteroid in severe sepsis management.