Prolonged exercise reduces Ca2+ release in rat skeletal muscle sarcoplasmic reticulum |
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Authors: | Terence G. Favero Isaac N. Pessah Gary A. Klug |
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Affiliation: | (1) Department of Exercise and Movement Science and Institute of Neuroscience, University of Oregon, 97403 Eugene, OR, USA;(2) Department of Pharmacology and Toxicology, School of Veterinary Medicine, University of California, 95616 Davis, CA, USA |
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Abstract: | Prolonged exercise decreased the rate of Ca+ release in sarcoplasmic reticulum (SR) vesicles isolated from rat muscle by 20–30% when release was initiated by 5, 10, and 20 M AgNO3. [3H]Ryanodine binding was also depressed by 20% in SR vesicles isolated from the exercised animals. In contrast, the maximum amount of Ca2+ released by Ag+ remained unaffected by exercise. The passive permeability of SR vesicles and the rate of Ca2+ release in the presence of ruthenium red, a known inhibitor of the Ca2+ release mechanism, was not affected by prolonged exercise. These results suggest that exercise depressed Ca2+ release from SR by directly modifying the Ca2+ release channel.Current address: Department of Physics, Portland State University, Portland, OR 97207, USA |
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Keywords: | Exercise Sarcoplasmic reticulum Ca2+ release |
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