泼尼松和米诺地尔联合治疗雄激素性秃发临床研究

目的 观察近生理剂量泼尼松、锌制剂联合2%米诺地尔治疗雄激素性秃发的临床疗效.方法 将98例雄激素性秃发患者按就诊先后1∶1比例,分为治疗组和对照组,治疗组口服近生理剂量泼尼松和自制锌制剂口服液联合2%米诺地尔酊外用,对照组仅口服近生理剂量泼尼松和自制锌制剂口服液.3个月为1个疗程,用药1～4个疗程分别观察疗效.结果 治疗后3、6个月治疗组有效率分别为10.2%(5/49)、36.7%(18/49),对照组分别为6.1%(3/49)、22.4%(11/49),两组比较差异无统计学意义(P＞0.05).治疗后9、12个月治疗组有效率分别为77.6%(38/49)、91.8%(45/49),对照组分别为42.9%(21/49)、59.2%(29/49),两组比较差异有统计学意义(P＜0.05).结论 近生理剂量泼尼松、锌制剂联合2%米诺地尔治疗雄激素性秃发的临床疗效满意,长期用药效果理想,安全性和耐受性良好.

Clinical study of combined prednisone with minoxidil in treatment of the androgenetic alopecia

Objective To investigate the clinical effect of prednisone and zinc preparation combined with 2％ minoxidil in the androgenetic alopecia. Methods Ninety-eight patients with the androgenetic alopecia were randomly divided into two groups, each group was 49 patients. The treatment group received prednisone and zinc preparation oral solution combined with 2％ minoxidil, the control group received only prednisone and zinc preparation oral solution. The each course of treatment was 3 months, the effect was observed after 1-4 courses of treatment. Results The curative rate of the treatment group and control group were 10.2％( 5/49 ) ,36.7％ (18/49) and 6.1％ (3/49) ,22.4％ (11/49) respectively in 3 and 6 months after treatment, there were no significant difference between two groups (P ＞ 0.05 ). The curative rate of the treatment group and control group were 77.6％ (38/49), 91.8％ (45/49) and 42.9％ (21/49 ), 59.2％(29/49) respectively in 9 and 12 months after treatment, there were significant difference between two groups (P＜ 0.05). Conclusion On treating the androgenetic alopecia, prednisone and zinc preparation combined with minoxidilis effective and safe.