| 舌癌瘤浸润性淋巴细胞与外周血淋巴细胞抗癌活性的比较 |
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| 引用本文： | 郭伟,何荣根,邱蔚六,张庆华,刘新垣,范佩芳. 舌癌瘤浸润性淋巴细胞与外周血淋巴细胞抗癌活性的比较[J]. 口腔颌面外科杂志, 1991, 0(2) |
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| 作者姓名： | 郭伟 何荣根 邱蔚六 张庆华 刘新垣 范佩芳 |
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| 作者单位： | 上海第二医科大学口腔医学院口腔颌面外科，上海第二医科大学口腔医学院口腔颌面外科，上海第二医科大学口腔医学院口腔颌面外科，上海第二医科大学口腔医学院口腔颌面外科，中科院上海生化所，上海第二医科大学口腔医学院口腔颌面外科 200011，200011，200011，200011，200011 |
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| 基金项目： | 上海市卫生局青年科研基金资助 |
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| 摘 要： | 肿瘤过继免疫治疗是近年研究的热门课题。如何获取有效足量,而且来源容易的抗瘤活性细胞是一关键性问题。由口腔内癌瘤制取TIL细胞存在两个问题:一是肿瘤体积较小,该得到治疗数量级的TIL较困难;二是口腔内肿瘤处在一个非无菌环境,制取的TIL细胞易污染。本文旨在通过实验研究,比较同一患者的肿瘤引流区的淋巴结细胞与LAK细胞体外抗瘤活性,为TIL过继免疫治疗提供理论根据。结果表明TIL对Tca8113细胞表现明显的杀伤作用,TIL与LAK细胞组比较,两组间存在显著性差别(P<0.05)。
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| 关 键 词： | 肿瘤浸润性淋巴细胞 LAK细胞 舌癌 ~(51)Cr释放实验 |
COMPARATIVE STUDY ON HUMAN TUMOR INFILTRATING LYMPHOCYTES (TIL) AND PERIPHERAL BLOOD LYMPHOCYTES FROM TONGUE CANCER PATIENTS IN ANTITUMOR ACTIVITY |
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| Abstract: | In this paper, antitumor activity of oral cancer-draining lymph node lymphocytes and its comparison with peripheril blood lymphocytes was studied.Cytotoxic activity against Tca8113 cell line target was assessed by ~(51)Cr release assay.The results show that l-5×10~8 lymphocytes are received per 1 gram lymph node tissue.Although fresh tumor-draining lymph node effectors were unable to kill Tca8113 cell targets, TIL-2 activited them from 6 tongue cancer patients did express signifcant cytotoxicity against Tca8113 cell targets This suggests that TIL in a broad sense may be obtained directly from tumordraininglymph node. |
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