Evidence that [Phe1 ψ(CH2-NH)Gly2]nociceptin-(1-13)-NH2, a peripheral ORL-1 receptor antagonist,acts as an agonist in the rat spinal cord |
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Authors: | Kate J Carpenter Anthony H Dickenson |
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Affiliation: | 1.Department of Pharmacology, University College London, Gower Street, London WC1E 6BT |
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Abstract: | [Phe1 ψ(CH2-NH)Gly2]nociceptin-(1-13)-NH2, a pseudopeptide analogue of nociceptin is an antagonist in peripheral assays. Here, using in vivo electrophysiological recordings of dorsal horn neurones, [Phe1 ψ(CH2-NH)Gly2]nociceptin-(1-13)-NH2 appears to have agonist activity after spinal administration. The noxious evoked activity of the neurones was inhibited by [Phe1 ψ(CH2-NH)Gly2]nociceptin-(1-13)-NH2, which was as potent as nociceptin itself. |
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Keywords: | nociceptin spinal cord ORL-1 receptor antinociception |
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