通脉颗粒治疗冠心病心绞痛的临床研究

目的观察通脉颗粒的临床疗效尤其是对冠心病心绞痛患者运动耐量和生活质量的影响.方法将47例劳力性心绞痛患者随机分为消心痛组(23例)和通脉颗粒组(24例),前者予消心痛10 mg tid,后者予通脉颗粒3 g Bid,观察比较两种药物的临床疗效及其副作用,并分别记录和评定治疗前、治疗一月、三月时一周内心绞痛发作次数和硝酸甘油用量以及运动耐量和生活质量;观察期间停用其它抗心肌缺血药物,若发生心绞痛,临时予硝酸甘油舌下含服控制.结果心绞痛患者服用通脉颗粒1个月时心绞痛发作次数及硝酸甘油用量明显减少,运动耐量和生活质量明显改善,总有效率79.2%,但较消心痛组疗效差;治疗三月时通脉颗粒疗效进一步提高,而消心痛疗效呈下降趋势,两组间有显著性差异(P＜0.05);整个观察进程中,消心痛组共6例发生不同程度头痛、颜面潮红、体位性低血压等副作用,而通脉颗粒组无1例发生此类现象.结论通脉颗粒治疗冠心病心绞痛有明显疗效,可明显减少心绞痛发作次数和硝酸甘油用量,明显改善患者运动耐量和生活质量,且3个月内在耐药性和药物副作用方面较消心痛有明显优势.

Clinic research of TongMai granules on angina pectoris

Objective: To observe the effects of TongMai granules especially on exercise tolerance and life quality of angina pectoris patients. Methods: (1) Forty-seven patients with stable angina petoris were randomly divided into two groups, one is the group of Isosorbide dinitrate (n=23) receiving Isosorbide dinitrate 10 mg tid, the other is the group of TongMai granules (n=24) receiving TongMai granules 3 g Bid. Symptomatic improvement and side effects were observed, angina pectoris attack frequency and nitroglycerin dosage within one week, exercise tolerance and life quality were recorded before, one months and three months after the treatment respectively. Other anti-ischemic nitoglycerin was administered. Results: Angina pectoris on TongMai granules, exercise tolerance and life quality were also improved markedly. Its total efficacy rate was 79.2%, but not as good as on the group of Isosobide dinitrate. In the third month the effects of TongMai granules improved further, while those of Isosorbide dinitrate declined. There is significant difference between in the two groups (P<0.05). Throughout the observation, headache, flush and postural hypotension occurred in six patients on Isosorbide dinitate, whereas no such occurrences were seen in the groups on TongMai. Conclusions: TongMai granules is effective in the tratment of angina pectoris, significantly reducing attack frequency, nitroglycerin dosage and improving exercise tolerance and life quality with less drug resistance and side effects compared with Isosorbide dinitrate.