Pharmacokinetics of quinine and doxycycline in patients with acute falciparum malaria: a study in Africa. |
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| Authors: | W Couet R Laroche J J Floch B Istin J B Fourtillan J F Sauniere |
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| Affiliation: | CEMAF s.a., Poitiers, France. |
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| Abstract: | The pharmacokinetics of quinine was investigated in patients with acute falciparum malaria treated with quinine alone or in the presence of doxycycline. Twenty-six patients divided into two groups of equal number were enrolled in the study. In the absence of doxycycline, the volume of distribution of quinine (mean +/- SD) was estimated to be 1.32 +/- 0.32 L/kg, and its clearance was 0.125 +/- 0.47 L/h/kg, which was only in partial agreement with previously published data. No effect of doxycycline on the pharmacokinetics of quinine was observed. |
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