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Management of sepsis in neutropenic patients: 2014 updated guidelines from the Infectious Diseases Working Party of the German Society of Hematology and Medical Oncology (AGIHO) |
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| Authors: | Olaf Penack Carolin Becker Dieter Buchheidt Maximilian Christopeit Michael Kiehl Marie von Lilienfeld-Toal Marcus Hentrich Marc Reinwald Hans Salwender Enrico Schalk Martin Schmidt-Hieber Thomas Weber Helmut Ostermann |
| Affiliation: | 1. Department of Hematology, Oncology and Tumourimmunology, Charité Campus Virchow Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany 2. Department of Oncology, Hematology and Stem Cell Transplantation, Medical Faculty, RWTH Aachen University, Aachen, Germany 3. 3rd Department of Internal Medicine, University Medical Centre Mannheim, University of Heidelberg, Heidelberg, Germany 4. Internal Medicine IV, Oncology and Hematology, University Hospital of Martin-Luther-University, Halle (Saale), Germany 5. Department of Hematology and Oncology, Klinikum Frankfurt Oder, Frankfurt, Germany 6. Department of Hematology and Oncology, University of Jena, Jena, Germany 7. Department of Hematology, Oncology and Palliative Care, Harlaching Hospital, Munich, Germany 8. Department of Hematology and Oncology, Asklepios Hospital Altona, Hamburg, Germany 9. Department of Hematology and Oncology, Medical Centre, Otto-von-Guericke University Magdeburg, Magdeburg, Germany 10. Clinic for Hematology, Oncology and Tumourimmunology, HELIOS Clinic Berlin-Buch, Berlin, Germany 11. 3rd Department of Internal Medicine, Ludwig-Maximilians University, Munich, Germany |
| Abstract: | Sepsis is a major cause of mortality during the neutropenic phase after intensive cytotoxic therapies for malignancies. Improved management of sepsis during neutropenia may reduce the mortality of cancer therapies. Clinical guidelines on sepsis treatment have been published by others. However, optimal management may differ between neutropenic and non-neutropenic patients. Our aim is to give evidence-based recommendations for haematologist, oncologists and intensive care physicians on how to manage adult patients with neutropenia and sepsis. |
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